Chronic kidney disease

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can reduce inflammation and improve heart function better than the standard filter in people with end-stage kidney disease. Thirty adults on maintenance hemodialysis will use each filter for three …

This trial tests a self-management program that uses education, WhatsApp reminders, and a diary to help hemodialysis patients control weight gain between sessions. The program aims to improve fluid adherence and stabilize blood pressure. Participants are adults on maintenance hem…

This phase 3 trial tests the drug atrasentan in 28 children aged 2 to 18 with IgA nephropathy, a kidney disease that can lead to kidney failure. The study measures whether atrasentan reduces protein in the urine, a sign of kidney damage, over 36 weeks. All participants receive th…

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests whether adding extra bicarbonate and magnesium to the fluid used during dialysis can improve how well the body handles minerals like calcium and phosphate. It involves adults with end-stage kidney disease who have been on dialysis for at least three months. Each …

This study tests whether a real-time continuous glucose monitor (CGM) helps people with type 2 diabetes and chronic kidney disease keep their blood sugar in a healthy range. Thirty adults will either use the CGM or stick with standard fingerstick checks for three months. The goal…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This pilot study tests whether adding a Chinese herbal formula called CKD-1 to standard care can improve kidney function in people with stage 3-4 non-diabetic chronic kidney disease. About 66 adults will be randomly assigned to receive either standard care alone or standard care …

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This pilot study will test whether adding a traditional Chinese herbal formula (DKD-1) to standard care can improve kidney function in people with diabetic kidney disease. Sixty-six adults with type 2 diabetes and moderate-to-severe chronic kidney disease will be randomly assigne…

This pilot study tests a new dialysis catheter coated with Endexo technology, designed to resist blood clots and reduce infections. Researchers will compare its performance to older catheters in 50 adults with end-stage kidney disease. If successful, it could improve quality of l…

This Phase 2 trial tests whether the drug SAL0140 can reduce protein in the urine, a sign of kidney damage, in 249 adults with chronic kidney disease. Participants will receive either SAL0140 or a placebo for 16 weeks. The goal is to see if the drug can help control the disease a…

This study compares two common ways to access the blood for dialysis: a tunneled catheter (a tube placed in a large vein) versus a surgically created fistula (connecting an artery to a vein). The trial will enroll 220 patients aged 60 or older (or younger but with multiple health…

This Phase 3 trial tests whether BHV-1400 can safely reduce protein in the urine and preserve kidney function in 420 adults with IgA nephropathy. Participants are randomly assigned to receive either the drug or a placebo by injection. The main goal is to see if BHV-1400 lowers pr…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This study tests whether giving specific blood pressure drugs based on a patient's circulation type during kidney transplant surgery improves how the body responds to fluids. Researchers will monitor 255 adults and assign drugs like vasopressin or norepinephrine based on real-tim…

This study tests a new medicine called ABP-671 in 80 adults with chronic kidney disease and high uric acid levels. Participants will receive either the drug or a placebo for 40 weeks. The main goal is to see if the drug reduces protein in the urine, a sign of kidney damage.

This large Phase 3 study tests whether the drug HRS-7535 can help people with chronic kidney disease (CKD) avoid serious outcomes like kidney failure, dialysis, or heart-related death. About 3690 adults with CKD will receive either the drug or a placebo, added to their usual care…

This early-stage trial tests a drug called CSL300 (clazakizumab) in 24 Chinese adults with end-stage kidney disease who are on dialysis. The drug is an antibody that blocks interleukin-6, a protein involved in inflammation. The main goal is to see how the drug moves through the b…

This phase 3 trial tests whether a combination of two drugs (balcinrenone and dapagliflozin) works better than dapagliflozin alone for people with advanced chronic kidney disease (stages 3b and 4). About 2,800 participants will take the combination or a placebo daily, alongside s…

This early-stage study tests a new drug called PMG1016 in 30 healthy adults to see if it is safe and how the body processes it. The drug is given as a single IV infusion. This is the first time PMG1016 is being tested in humans, and it aims to gather safety data before moving to …

This Phase 2 study will test whether empagliflozin (Jardiance), a drug already used for diabetes, can improve blood vessel health and exercise tolerance in 52 veterans with non-diabetic chronic kidney disease. Participants will take either the drug or a placebo for a period, and …

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study will test whether a supplement made from jaboticaba peel can reduce inflammation, oxidative stress, and gut bacteria imbalances in people with chronic kidney disease. Thirty adults will take either the jaboticaba extract or a placebo for one month. Researchers will mea…

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This study tests whether a structured, goal-directed care plan can help people with diabetic kidney disease better manage their kidney and heart health. About 100 adults with type 2 diabetes and kidney disease will either receive this focused care or standard treatment. The goal …

This trial tests a new type of vascular graft, called STARgraft, for people with end-stage kidney disease who need hemodialysis. The graft is placed in the arm to create a reliable access point for dialysis. The study compares STARgraft to a standard graft to see if it works bett…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study tests a new medicine called HS-10390 in 182 adults with chronic kidney disease. The goal is to see if it can lower protein levels in urine, a sign of kidney damage, better than standard care. Participants must already be on stable blood pressure medication and have mod…

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This study tests whether adding a weekly injection called dulaglutide to two standard pills (SGLT-2 inhibitors and finerenone) can better protect the kidneys of Chinese adults with type 2 diabetes and mild-to-moderate chronic kidney disease. About 468 participants will be randoml…

This study tests whether adding pea fiber to the daily diet of people on dialysis can lower harmful waste products in their blood. 72 adults on dialysis will eat baked goods with or without pea fiber for 8 weeks. Researchers will measure changes in toxin levels and heart health m…

This trial tests a new feature called FlexPoint on a peritoneal dialysis machine used at home. The feature adjusts fluid volume and dwell time during treatment. Researchers will compare three different settings in 24 adults with chronic kidney disease to see which works best for …

This study tests an extended-release vitamin D capsule (CTAP101) in 40 children aged 8 to 17 with stage 3 or 4 chronic kidney disease, secondary hyperparathyroidism, and low vitamin D. Participants take one capsule daily at bedtime for 8 weeks. The goal is to see how the body pro…

This study tests whether an investigational drug called HTD1801 can slow the worsening of kidney disease in adults who have both type 2 diabetes and chronic kidney disease. About 75 participants will take either HTD1801 or a placebo twice daily for 12 weeks. Researchers will meas…

This early-stage trial tests whether treating a donor kidney with a drug called SYN002 before transplant can safely reduce the risk of passing cytomegalovirus (CMV) to the recipient. About 12 adults waiting for a kidney transplant will receive a treated organ. The main goal is to…

This study tests whether a combination of a controlled diet, structured exercise, and a symbiotic supplement can reduce inflammation and harmful gut toxins in young people with early chronic kidney disease (stages 1-3). Two hundred participants will receive either the multimodal …

This study tests a Traditional Chinese Medicine (TCM) herbal formula, Jiajian Yishen Xiaozheng Qufeng Granules, combined with AI-driven diagnostics to treat diabetic nephropathy (kidney disease from type 2 diabetes). About 198 adults with mild-to-moderate kidney damage will recei…

This early-stage study tests whether injecting human umbilical cord stem cells can prevent narrowing of the arm vein used for dialysis in people with end-stage diabetic kidney disease. About 54 participants will receive the stem cell treatment after fistula surgery. The goal is t…

This study tests whether a daily synbiotic supplement (probiotics plus prebiotics) can lower inflammation and improve digestive symptoms in adults with chronic kidney disease stages 3 to 5 who are not yet on dialysis. One hundred participants will receive either the supplement or…

This early study tests a new medicine called TNX-1500 in 5 people who get a kidney transplant. The goal is to see if it is safe and can help prevent the body from rejecting the new kidney. Participants will be followed for one year to check for side effects and signs of rejection…

This study tests a traditional Chinese herbal formula for people on dialysis who often have dangerously low blood pressure during treatment. About 100 adults with kidney failure will either get the herbs or stay on a waitlist. The goal is to see if the herbs reduce low blood pres…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether adding a low-dose blood thinner (apixaban) to the standard heparin lock can help dialysis catheters stay functional longer. Fifty-four adults with end-stage kidney disease and a new catheter will be followed for up to 24 months. The goal is to see if this…

This pilot study tests whether an AI-based system can help doctors choose the right doses of immunosuppressant drugs for kidney transplant patients. The goal is to protect the new kidney from damage and rejection. The study will enroll 34 adults who have received a deceased donor…

This early-stage trial tests whether giving kidney transplant recipients a special treatment made from their donor's cells, combined with a light-based therapy called photopheresis, can safely reduce the risk of organ rejection. About 24 adults receiving their first kidney transp…

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either the drug or standard care for 2 years. Researchers will track kidney funct…

This study tests whether giving amino acids through the dialysis machine twice a week for a year can help protect the heart and blood vessels in people with kidney failure. About 120 adults on stable dialysis will receive either amino acids or a placebo (saline). Researchers will…

This study tests imlifidase, a drug that temporarily disables the immune system's antibodies, allowing highly sensitized patients to receive a kidney from a deceased donor they would otherwise reject. The trial will follow 450 patients in France to see how many get transplanted a…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This study tests whether using two daily exchanges of a special dialysis fluid called icodextrin can better control fluid buildup and blood pressure in children on chronic peritoneal dialysis. Ten children aged 5-18 will be enrolled. The goal is to see if this approach improves f…

This early-phase study tests whether adding the drug venetoclax to standard transplant preparation is safe for people with chronic kidney disease and a blood cancer. Only 3 adults aged 18-70 will take part. The goal is to see if the combination helps the new stem cells and kidney…

This study tests whether taking a laxative (bisacodyl) for two days before getting a peritoneal dialysis catheter can prevent blockages. About 398 adults needing dialysis will be randomly assigned to receive the laxative or usual care. The goal is to see if this simple step reduc…

This study will test whether SGLT2 inhibitors, a type of diabetes drug, can help correct anemia in people with chronic kidney disease (CKD). Anemia is common in CKD and often requires iron or hormone injections, which have side effects. The trial will enroll 60 adults with CKD st…

This early study will test whether gentle ultrasound pulses applied to the kidneys can improve kidney function in 20 adults with chronic kidney disease (CKD). Participants will receive the ultrasound treatment three times a week for four weeks. Researchers will measure changes in…

This study tests whether the drug finerenone can slow kidney function decline and lower heart failure risk in 120 adults with type 2 diabetes and chronic kidney disease. Participants must already be on standard blood pressure medications. The study will measure changes in kidney …

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This early-stage trial tests whether a single intravenous infusion of stem cells from donated umbilical cord tissue can safely improve kidney function in 32 adults with stage 3 or 4 chronic kidney disease caused by diabetes or high blood pressure. Participants will be randomly as…

This study tests a new drug called VEL-101 in 120 kidney transplant patients. The goal is to see if VEL-101 can safely replace the standard drug tacrolimus, which often causes side effects. Researchers will monitor for rejection, side effects, and how the drug behaves in the body…

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or obesity. Participants receive weekly injections for three months. The goal is to see if this drug can help manage weight and …

This study looks at whether roxadustat, a drug for anemia in chronic kidney disease, can also help people with heart failure. Researchers will review medical records of 200 patients who took roxadustat for at least a year. They will check heart function, symptoms, and major event…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

This study looks at whether giving extra nutrition during dialysis sessions helps people on long-term hemodialysis build muscle and manage blood pressure. Researchers will compare the effects of this special nutrition with usual care in 16 adults who have been on dialysis for at …

This study looks at whether eating more protein can help people on dialysis avoid hospital stays. Dialysis removes nutrients like protein from the blood, and current guidelines are based on old research. The study will give some participants a high-protein diet or supplements and…

This study tests whether the drug finerenone can protect the retina (the light-sensitive layer at the back of the eye) in people with chronic kidney disease. Researchers will measure changes in retinal nerve thickness over time in 40 adults with stage 2-4 kidney disease. The goal…

This study tests whether adding ganagliflozin tablets to standard care can slow kidney disease progression in 1,244 adults with type 2 diabetes and chronic kidney disease. Participants will take either ganagliflozin or a placebo daily for 120 weeks. The main goal is to measure ch…

This phase 2 trial tests whether combining dapagliflozin (a diabetes drug) with SC0062 (a blood vessel drug) can better protect kidneys in adults with type 1 diabetes and chronic kidney disease. Thirty-six participants will try each treatment alone and together in a cross-over de…

This study tests a weekly injection called survodutide in 120 people with chronic kidney disease and high protein in their urine. The goal is to see if the drug can lower protein levels and protect kidney function over 36 weeks. Participants must be on stable standard treatments …

This study tests two different drug combinations to prevent cytomegalovirus (CMV) infection in kidney transplant patients who are at high risk. Thirty adults who are CMV-positive before transplant will receive either tacrolimus plus mTOR inhibitors with early antiviral treatment,…

This study tests whether adding levocarnitine injections to standard care can lower the amount of anemia medication needed by people on hemodialysis. About 94 adults with kidney failure and anemia will receive either levocarnitine after each dialysis session or usual care alone f…

This study tests whether roxadustat, a drug currently used to treat anemia in kidney disease, can also improve sarcopenia (muscle loss) in patients on hemodialysis. Sixty adults with end-stage kidney disease and anemia will receive either roxadustat or standard erythropoietin. Re…

This trial tests a new drug called QRX3 in 3,000 people with chronic kidney disease whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow the need for dialysis. Participants take QRX3 capsules, and researchers measure changes in kidne…

This study tests whether a citrate-based dialysis fluid with extra magnesium can slow or prevent blood vessel hardening in adults on long-term hemodialysis. Eighty stable patients will receive either the new fluid or a standard one for 12 months. Researchers will measure blood ma…

This study tests two drugs, finerenone and empagliflozin, in 30 African American veterans with diabetic kidney disease. The goal is to see if these drugs reduce kidney cell damage by measuring specific proteins in urine. Participants will take one or both drugs for 4 months to ch…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This pilot study tests a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow in tiny vessels of transplanted kidneys. The goal is to see if changes in these vessels can predict how well the kidney will work early after transplant, includin…

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study looks at whether measuring a hormone called irisin in the blood can help find diabetic kidney disease early and track how it gets worse. Researchers will compare irisin levels in 200 adults with type 2 diabetes to healthy people. The goal is to see if irisin can be a s…

This study will check if a new urine test can find early signs of chronic kidney disease and track its progress. Researchers will also look at how well common diabetes drugs (SGLT2 inhibitors) help protect the kidneys. About 300 adults with mild-to-moderate kidney disease will ta…

This study looks at whether the triglyceride-glucose (TyG) index, a simple measure from a blood test, can predict insulin resistance in people with pre-diabetes and chronic kidney disease. Researchers will enroll 60 adults with and without kidney problems to see how well the TyG …

This study will test a new handheld device that measures creatinine (a kidney health marker) from a fingerstick blood sample at home. Researchers will compare its accuracy to standard lab tests and ask 200 adults with kidney disease to try the device and rate how easy it is to us…

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests an 8-week health literacy program designed to help people aged 55-74 who take 5 or more medications daily. The goal is to see if the program improves their understanding of medication management and reduces their risk of developing chronic kidney disease. Half of…

This study compares two treatments—Plazepod and electrical stimulation—to see which better reduces fall risk in people on hemodialysis. Sixty men aged 40 to 50 with end-stage kidney disease will be followed for changes in balance, leg strength, and mobility. The goal is to find a…

This study tests whether a simple home exercise program can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4-5). 124 participants will either do low-intensity walking and strength exercises or receive standard care. …

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether a new intravenous drug, Anrikefon, can improve sleep quality better than a standard oral medication (nalfurafine) in people with chronic kidney disease who suffer from severe itching and are on hemodialysis. Fifty adults will receive either Anrikefon inje…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study tests whether doing simple handgrip exercises at home for 8 weeks can lower blood pressure in people with chronic kidney disease (CKD). Researchers will measure changes in resting blood pressure, blood vessel function, and stiffness. The study involves 50 adults aged 4…

This pilot study tests a 16-week physical activity and power training program for up to 30 older Veterans with advanced chronic kidney disease. The main goal is to see if the program is doable and well-tolerated. Participants will be pre-frail or have difficulty walking, and the …

This early study tests a new device that lets dialysis patients use just one needle instead of two for their blood cleaning treatments. The goal is to see if it is safe and works well for people who already have a mature vein connection (fistula). About 20 adults who need dialysi…

This pilot study will test whether a short eye-exercise program done during dialysis sessions can improve physical function, balance, and fear of falling in people with kidney failure. Thirty adults on maintenance hemodialysis will be randomly assigned to do the exercises or rece…

This study looks at whether coloring mandalas (circular patterns) can improve mindfulness, mood, and reduce psychological distress in people undergoing hemodialysis for kidney failure. Sixty adults aged 18-50 will be split into two groups: one colors mandalas, the other does free…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This study tests whether acupuncture laser therapy can reduce neck pain and improve quality of life in people undergoing hemodialysis. Sixty participants will either receive standard care or standard care plus laser therapy three times a week for four weeks. Researchers will meas…

This study tests whether reflexology (foot massage) or progressive muscle relaxation can reduce fatigue in people on hemodialysis. Sixty patients aged 50-70 will be split into three groups: reflexology, relaxation, or standard care. Fatigue and sleep quality will be measured afte…

This study tests whether Anakinra, a drug that reduces inflammation, can prevent dangerous drops in blood sugar after meals in a patient who had his stomach removed. The 52-year-old man also has kidney failure and needs dialysis. Over 10 weeks, he will receive either Anakinra or …

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study tests whether using virtual reality (VR) during arteriovenous fistula surgery—a procedure for dialysis patients—can lower pain, anxiety, and the need for anesthesia. About 64 adults with end-stage kidney disease will be randomly assigned to receive VR or standard care …

This study tests whether laser acupuncture can reduce fatigue and improve quality of life in adults with end-stage kidney disease who are on dialysis. Fifty participants will receive either real laser acupuncture or a sham treatment during their regular dialysis sessions three ti…

This trial tests whether the drug difelikefalin can reduce severe itching in people with chronic kidney disease who are on hemodialysis. About 106 adults will receive either the drug or a placebo after each dialysis session for 6 weeks. The main goal is to see if itching scores i…

This study tests whether a special teaching method called Pecha Kucha can help people on hemodialysis better follow their fluid and diet restrictions. The method uses a fast, visual slideshow to make information easier to remember. 70 patients will be split into two groups: one g…

This study tests whether doing progressive relaxation exercises at times matched to each patient's natural circadian rhythm can help manage symptoms, improve sleep quality, increase comfort, and boost mental well-being in people receiving hemodialysis. Researchers will enroll 75 …

This study tests whether a nurse-led program of laptop-based education, phone reminders, and a booklet can help people on hemodialysis better follow their diet and fluid restrictions, be more active, and improve their quality of life. About 112 adults who have been on dialysis fo…

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random …

This early-stage study tests whether bupropion, a medicine used for smoking cessation and depression, can reduce severe tiredness in people with end-stage kidney disease on dialysis. Sixteen participants will take bupropion three times a week for 8 weeks and report their fatigue …

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This study looks at whether hydromorphone sustained-release tablets can safely relieve moderate to severe cancer pain in elderly patients who also have kidney issues. Researchers will compare these patients to those with normal kidney function, monitoring pain relief, kidney func…

This study tests whether combining relaxation exercises with listening to a specific Quran chapter (Surah Ar-Rahman) can reduce anxiety and improve sleep in people undergoing kidney dialysis. 76 adult Muslim patients will be split into two groups: one doing the relaxation and Qur…

This study looks at whether doing joint range-of-motion exercises and Benson relaxation techniques during dialysis can improve how well the treatment works, help patients follow their care plan, and boost quality of life. About 72 adults on long-term hemodialysis will take part. …

This study will test whether a sodium bicarbonate enema can help relieve constipation and reduce harmful waste products in people with chronic kidney disease (CKD). The researchers believe the gut can act as an extra filter to remove toxins that build up when kidneys fail. They p…

This study tests whether adding a special breathing feedback device to standard breathing exercises can reduce symptoms and improve quality of life in adults with chronic kidney disease. Twenty-four participants will practice the exercises three times daily for six weeks. The goa…

This study compares a new 'tubeless' anesthesia method (using a laryngeal mask and lighter sedation) to standard breathing-tube anesthesia in 60 kidney transplant patients. The goal is to see if it reduces the need for muscle relaxants and other drugs, and improves recovery. Part…

This study tests whether wearing virtual reality (VR) glasses during needle insertion can reduce pain and anxiety in hemodialysis patients. 150 adults with end-stage kidney disease will either receive standard care or watch a calming 360-degree underwater video through VR goggles…

This study looks at whether doing aerobic or free exercises during dialysis sessions can reduce fatigue, improve walking ability, and help thinking in people with kidney failure. Sixty-nine adults aged 50 to 60 on maintenance hemodialysis will be assigned to different exercise ro…

This study tests whether doing virtual reality exercise during dialysis can help patients with end-stage kidney disease keep their electrolytes (sodium, potassium, calcium, phosphorus) in a healthier range. Forty adults on regular dialysis will either do 30 minutes of VR cycling …

This study tests whether breathing low-oxygen air during exercise (simulated high-altitude training) can improve walking ability and reduce fatigue in people with stage 3-4 chronic kidney disease. Sixty adults aged 40-65 will be split into three groups: simulated altitude trainin…

This study tests whether a smartphone app with artificial intelligence can help people on hemodialysis take better care of themselves. The app provides education on diet, fluid intake, and fistula care, and sends reminders. 76 patients will be randomly assigned to use the app or …

This study tests whether a relaxation method called autogenic training can help people on hemodialysis who suffer from restless leg syndrome, poor sleep, and fatigue. About 54 adults aged 45-55 will practice guided relaxation exercises for 8 weeks. Researchers will measure change…

This study tests whether taking probiotics daily can help chronic kidney disease patients on dialysis better respond to anemia medication (erythropoietin). About 80 adults will receive either erythropoietin alone or erythropoietin plus probiotics for 3 months. Researchers will tr…

This study tests whether walking at home for 30 minutes, 5 days a week, can reduce symptoms like muscle cramps and improve overall health in people on hemodialysis. Twenty-four adults who can walk independently and own a smartphone will be tracked for 8 weeks. The goal is to see …

This study tests whether a smartphone app that guides patients through acupressure can reduce fatigue, itching, and improve sleep in people on hemodialysis. About 70 adults who have been on dialysis for at least three months will be randomly assigned to use the app daily for four…

This study tests whether therapeutic touch—a gentle, non-invasive technique—can lower stress and boost comfort in people on hemodialysis. About 60 patients will be randomly assigned to receive touch sessions or standard care only. Researchers will measure stress and comfort level…

This study tests a mobile app designed for people on hemodialysis. The app helps with medication, diet, fluid limits, and symptom tracking. 72 adults will be split into two groups: one uses the app, the other gets standard care. Researchers will check if the app improves treatmen…

This study looks at whether listening to music during dialysis sessions can help reduce fatigue, improve sleep quality, and boost mental well-being. Sixty adults on hemodialysis will receive 30 minutes of music therapy after the second hour of each session for four weeks. Researc…

This study will test a mobile app called Smart Kidney that helps adults with chronic kidney disease track and manage their symptoms remotely. Sixty participants in Vietnam will use the app for 6 weeks. The goal is to see if the app is easy to use and helpful for symptom managemen…

This study will test whether a 16-week Pilates exercise program can reduce restless leg syndrome, improve physical function, and boost self-perception in 100 older adults (65+) who are on maintenance hemodialysis. Participants will do supervised resistance exercises two to three …

This study planned to test whether kidneys with small, low-risk tumors could be removed from donors, have the tumor taken out, and then be transplanted into patients with kidney failure. The goal was to increase the number of available donor kidneys. However, the study was withdr…

This study examines how the severity of chronic kidney disease (CKD) affects the breakdown of a protein called FGF23, which is linked to bone health, anemia, and heart problems. Researchers will measure different forms of FGF23 in blood samples from 80 men with CKD stages 3a to 5…

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

This study tests whether nurses can accurately identify depression in people on hemodialysis. About 450 patients will have their depression symptoms assessed both by a nurse and by themselves using a standard questionnaire. The goal is to see if nurse assessments can be a reliabl…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study explores how Black and Caucasian patients with kidney disease communicate with their transplant doctors during evaluation visits. Researchers will record these conversations and survey patients to find out which communication styles lead to more living donor referrals …

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study follows 150 adults waiting for a kidney transplant to track how their physical and emotional health changes over time. Researchers will use a mobile app and interviews to measure frailty and quality of life. The goal is to identify patients who need extra support and i…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This study looks at two ways to prevent blood clots during dialysis in people with end-stage kidney disease. Twenty adults will try both methods—one using standard heparin and the other using a citrate-based approach—to see which causes less inflammation and removes waste better.…

This study will look at how people with chronic kidney disease use a digital app called MyRenalCare. Researchers want to see if the app helps improve health, lowers hospital visits, and reduces costs and environmental impact. About 1,000 adults under kidney care will be included.

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This study looks at why dialysis patients often have heart problems that are hard to detect. Researchers will use a special heart test during a routine procedure to check for tiny blood vessel issues in 30 adults who have been on dialysis for at least 6 months. The goal is to fin…

This study tests whether a pop-up alert in electronic medical records helps doctors prescribe more recommended medications for chronic kidney disease (CKD). About 1,000 patients with CKD will be included, and their doctors will either see the alert or not. The goal is to see if t…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study looks at how the amount of phosphorus in food affects phosphorus and calcium balance in people with moderate chronic kidney disease (CKD). Fourteen participants will follow two different controlled diets (low phosphorus then high phosphorus, or vice versa) for 19 days …

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This study looks at whether a blood test measuring the ratio of two substances (IGF-1 and albumin) can help identify muscle loss (sarcopenia) in people with end-stage kidney disease on dialysis. Researchers will compare the test results to standard muscle assessments in 110 adult…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study looks at whether adding a machine-learning risk label to electronic health record messages helps adults aged 65 and older better understand their risk of developing diabetes. About 1,200 participants with prediabetes will receive either standard lab results or results …

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This study will measure the thickness of the carotid artery wall in 100 adults on hemodialysis. The goal is to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to artery thickness. No new t…

This very early study (Phase 1) will give a single dose of a radioactive-labelled drug called HRS-1780 to 6 healthy men. The goal is not to treat disease but to track exactly how the drug is absorbed, broken down, and eliminated from the body. Results will help design future stud…

This study looks at whether men and women on hemodialysis have different dynamic balance, measured by simple tests like standing up and walking. About 155 patients aged 20-60 will participate. No treatment is given—just observation to gather information.

This study looks at why fluid builds up around the lungs in people with advanced chronic kidney disease (CKD). Researchers will test 100 adults to see if standard diagnostic methods work well for these patients. The goal is to improve accuracy so doctors can treat the right cause…

This study will observe 50 children (ages 1 month to 18 years) who come to the emergency room with kidney-related symptoms like swelling, blood in urine, or high blood pressure. Researchers want to learn which kidney diseases are most common and how children respond to initial tr…

This study tests whether a short course of belimumab, a drug used for lupus, can improve detection of immune cells that cause transplant rejection. The goal is to help highly sensitized kidney transplant candidates—people whose immune systems are very picky about donor organs—get…

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease may be related. Researchers will examine mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role in the link between the two conditions. The goal is to bett…

This study will survey 160 adults on long-term hemodialysis at Sohag University Hospital to find out how many experience anxiety or depression. Researchers will also look for links to age, gender, and other health factors. The goal is to better understand the mental health needs …

This study looks at whether eating a high-protein meal changes kidney function in a way that can be measured by a skin sensor. Researchers will give 25 adults an injection of a fluorescent dye and track how quickly it clears from the body before and after the meal. The goal is to…

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study tests whether shorter or standard-length dialysis sessions using expanded hemodialysis can remove waste products from the blood as well as a more intensive technique called high-volume hemodiafiltration. Fifteen adults with end-stage kidney disease will try three diffe…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study will follow 225 adults with end-stage kidney disease who are on regular dialysis. Researchers want to see if missing a dialysis session raises the risk of heart problems like heart attack or stroke within the next 72 hours. Participants will have heart tests after a mi…

This study will follow 290 Mexican adults with advanced chronic kidney disease who are on dialysis (hemodialysis or peritoneal dialysis). Researchers will track how many patients die, how often they are hospitalized, and how many infections they get. The goal is to better underst…

This pilot study will test whether a potassium-containing salt substitute is safe for people with end-stage kidney disease on hemodialysis. Twenty participants will use the salt substitute for 16 days and regular table salt for 16 days, with a break in between. Researchers will m…

This study looks at whether a new way of measuring kidney function (using an injection of iohexol and finger-prick blood tests) can better predict when people with advanced kidney disease will start feeling sick from kidney failure. It also checks if this method can accurately me…

This study will survey 400 adults with moderate to severe chronic kidney disease in Réunion Island to find out how many use herbal medicines and whether those herbs affect how fast their kidney disease gets worse over one year. Participants will fill out questionnaires about thei…

This study looks at whether using a patient's permanent dialysis access (a fistula or graft) instead of a temporary catheter is safe and effective for delivering continuous kidney replacement therapy in the ICU. Researchers will enroll 50 adults with end-stage kidney disease who …

This study surveys 200 adults (patients and caregivers) to learn what matters most when moving from peritoneal dialysis at home to hemodialysis in a clinic. The goal is to improve care and support during this transition. No treatments or medications are tested—only opinions and p…

This observational study looks at whether a diet that promotes inflammation can make gum disease worse in people with chronic kidney disease. Researchers will assess the diets and gum health of 100 adults with kidney disease. The goal is to understand if eating more inflammatory …

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study looks at whether ultrasound can help predict a sudden drop in blood pressure when ICU patients start a type of dialysis. Researchers will monitor 80 adults using heart and body scans before and during treatment. The goal is to find early warning signs to prevent compli…

This study tests whether a digital program (videos, texts, and optional phone support) can help people with kidney failure get more inquiries from potential living donors. About 430 adults referred for a kidney transplant will be randomly assigned to get the program with or witho…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at how potassium from fresh foods (like fruits and vegetables) versus processed foods affects blood potassium levels in people with chronic kidney disease (stages 3B-5). Participants will try four different 10-day diets, all provided for free, to see which foods …

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This observational study will check how common left ventricular hypertrophy (thickening of the heart muscle) is in people with chronic kidney disease. It will also look at whether treating anemia with erythropoietin can reduce that thickening. About 100 adults with moderate to se…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at 270 adults with diabetic kidney disease to see if gut bacteria and blood chemicals influence blood sugar swings and disease progression. Researchers will track participants over time using continuous glucose monitors and stool/blood samples. The goal is to fin…

This observational study will follow 200 hospitalized adults with chronic kidney disease to see how diabetes and related metabolic problems affect their outcomes. Researchers will track deaths, need for dialysis, and major heart events during the hospital stay. The goal is to bet…

This early study tests a wearable device that listens to the sound of blood flow in the arm of people on dialysis. The goal is to see if the device can accurately measure the same signals as a standard stethoscope. Six adults with mature fistulas will wear the device weekly for 8…

This study will collect data from 300 kidney transplant patients who receive kidneys from older or higher-risk donors. The kidneys are kept on a machine that pumps cold fluid through them before transplant. Researchers will see if the machine's readings (like flow and pressure) c…

This study will follow 1000 adults with advanced chronic kidney disease (stage 4-5) to learn why they face higher risks of bone fractures and heart disease. Researchers will track bone turnover markers, calcium and phosphate levels, and kidney function over time. No new treatment…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This study looks at two standard methods of stitching the kidney artery during a living donor kidney transplant: interrupted sutures and continuous sutures. Researchers will review past cases and follow 70 new adult patients at Assiut University to see which technique leads to sh…

This study will use advanced MRI scans and blood tests to explore how SGLT2i medications protect the kidneys in 100 people with diabetic kidney disease who are at risk of worsening. Participants will already be taking SGLT2i as part of their routine care. The goal is to identify …

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will measure levels of lipoprotein A, a type of fat in the blood, in 300 people with stage 4 chronic kidney disease. Researchers want to see if high levels are linked to future heart attacks, strokes, or worsening kidney function over 18 months. The goal is to find a b…

This small pilot study tests a simple tool called CKD Topics that helps people with advanced chronic kidney disease (stages 4-5) set the agenda for their doctor visits. The study includes 30 patients, their care partners, and clinic staff from rural areas. The goal is to see if t…

This study will examine why some people with chronic kidney disease in Spain may have a harder time getting a kidney transplant than others. Researchers will survey 3,000 patients and interview doctors and patients to understand barriers like age, income, or where someone lives. …

This study will test 200 adults on regular hemodialysis at Sohag University Hospital for latent tuberculosis infection (LTBI) using a simple skin test. The goal is to find out how many dialysis patients carry the bacteria without symptoms, so doctors can better prevent active TB …

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This study looks at 1,700 people with heart disease to see how different treatments—surgery, stents, or medication—affect kidney function over 5 years. Researchers will track changes in kidney health and check for new or worsening kidney disease. The goal is to help doctors choos…

This observational study tests whether tiny chemicals in breath, called VOCs, can show if a hemodialysis session is effective. About 22 dialysis patients and 23 healthy adults will provide breath and blood samples. The goal is to find a simple, non-invasive way to assess dialysis…

This study will use echocardiography (ultrasound of the heart) to look at how common and how severe diastolic dysfunction—a type of heart stiffness—is in 100 adults with end-stage kidney disease who are on regular hemodialysis. Researchers will also check if certain clinical fact…

This study will check if certain blood markers—like MCP-1, NLR, and hsCRP—can help detect kidney disease early in people with type 2 diabetes. Researchers will measure these markers in 80 adults and compare them to standard kidney tests. The goal is to find a simpler way to ident…

This study looks at how eating habits relate to the progression of chronic kidney disease in 160 adults with type 2 diabetes. Researchers will track changes in kidney function over 6 months. The goal is to find dietary patterns that might help protect the kidneys.

This study looks at how CMV (a common virus) changes the immune system in people who have had a kidney transplant. Researchers will take blood samples from 60 patients to compare immune responses in those with and without CMV infection. The goal is to understand why CMV may incre…

This study will check 100 adults on long-term hemodialysis for thyroid problems, abnormal cholesterol, and high uric acid. Researchers want to see how common these issues are and how they relate to each other. The goal is to better understand the health challenges faced by people…

This study will examine how quality of life changes after parathyroid surgery in 60 adults with kidney failure and secondary hyperparathyroidism. Researchers will use a database to compare quality-of-life scores, anxiety, and depression before and after surgery. The goal is to be…