Dialysis's hidden water waste: can a simple flow change cut consumption without harming patients?

NCT ID NCT07718568

Not yet recruiting Disease control Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether reducing the dialysate flow rate during hemodialysis from the standard 500 mL/min to 400 mL/min can maintain adequate blood cleansing while cutting water use. About 250 adults on chronic hemodialysis will each try both flow rates for one month. The main goal is to see if the lower rate is non-inferior in terms of urea removal, a key measure of dialysis quality.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dialysate flow rate of 400 mL/min compared to 500 mL/min
What this could lead to: If successful, this could help dialysis centers use less water without compromising patient care, making treatment more environmentally sustainable.
What could go wrong: This is a small, single-center trial. Lowering the flow rate might slightly reduce dialysis efficiency, and the long-term safety data are limited.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY DISEASE, CHRONIC

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Assistance Publique - Hôpitaux de Marseille

Marseille, France

Contact Phone: •••-•••-•••• Email: •••••@•••••

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