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Dialysis's hidden water waste: can a simple flow change cut consumption without harming patients?

NCT ID NCT07718568

Disease control Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether reducing the dialysate flow rate during hemodialysis from the standard 500 mL/min to 400 mL/min can maintain adequate blood cleansing while cutting water use. About 250 adults on chronic hemodialysis will each try both flow rates for one month. The main goal is to see if the lower rate is non-inferior in terms of urea removal, a key measure of dialysis quality.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dialysate flow rate of 400 mL/min compared to 500 mL/min
What this could lead to
If successful, this could help dialysis centers use less water without compromising patient care, making treatment more environmentally sustainable.
What could go wrong
This is a small, single-center trial. Lowering the flow rate might slightly reduce dialysis efficiency, and the long-term safety data are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Oct 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * No decompensated psychiatric disorder, acute or decompensated somatic condition * Patients on hemodialysis for more than 3 months * Dialysis schedule: 3 times per week for 4 hours each session * Stable vascular access (arteriovenous fistula or tunneled central catheter) * Blood flow \> 300 mL/min * Anuric (urine output \< 500 mL/24 h) * Dialysis method: hemodialysis or hemodiafiltration Exclusion Criteria: * Age \< 18 years * Patient on dialysis for \< 3 months * Unstable vascular access * Blood flow rate \< 300 mL/min * Urine output \> 500 mL/day * Dialysis technique: hemofiltration * Severe intercurrent condition (somatic or psychiatric) * Pregnant or breastfeeding patients. * Patients who are legally incapacitated, under guardianship, or under conservatorship

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney disease, chronic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assistance Publique - Hôpitaux de Marseille

    Marseille, France

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