Fish oil may unlock heart protection for dialysis patients

NCT ID NCT07730385

Not yet recruiting Disease control Sponsor: Medical University of Vienna Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

People on maintenance hemodialysis face a high risk of heart disease, and standard cholesterol drugs often fail to help. This trial tests whether high-dose fish oil (4 grams daily for 8 weeks) can improve the function of HDL, the 'good' cholesterol, which may become faulty in kidney failure. Forty adults on dialysis will take part in a crossover study, with each person receiving fish oil and a period without it. The main goal is to measure how well HDL removes cholesterol from cells, which could explain a recent finding that omega-3s reduce heart events in this group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fish oil (omega-3 fatty acids)
What this could lead to: If omega-3s improve HDL function, this could point toward a way to lower heart disease risk in people on dialysis.
What could go wrong: This is a small, early mechanistic study, not designed to prove clinical benefit. The results may not lead to changes in treatment.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE HDL CHOLESTEROL KIDNEY FAILURE, CHRONIC

Contacts and locations

Locations

Chronic Hemodialysis Unit, Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna

Vienna, State of Vienna, 1090, Austria

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