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Saliva test may uncover hidden gum disease in heart patients

NCT ID NCT07721428

Knowledge-focused Sponsor: Suleyman Demirel University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This observational study investigates whether levels of certain enzymes (ACE and ACE2) in saliva and blood are linked to the severity of gum disease in adults with cardiovascular disease. Researchers will compare these enzyme levels across different stages of gum disease—from gingivitis to advanced periodontitis—in 76 participants. The goal is to better understand the biological connection between oral health and heart health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a link is found, it could point toward new ways to detect or monitor gum disease in people with heart conditions using simple saliva tests.
What could go wrong
This is an observational study, not a treatment trial, so it cannot prove cause and effect. Results may not apply to people without heart disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

76 people

The number who actually took part.

Started

Mar 2021

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Between March 1, 2021, and June 12, 2021, a total of 113 symptomatic adults attending the Cardiology and Periodontology clinics of Süleyman Demirel University underwent diagnostic coronary angiography because of suspected myocardial ischemia based on clinical symptoms or non-invasive test findings. Significant coronary artery disease was defined as ≥50% luminal stenosis in at least one major epicardial coronary artery, as determined by visual assessment using the standard Judkins technique. Of the 113 individuals screened, 24 were excluded because they did not meet the eligibility criteria, and 13 declined to participate. Consequently, 76 participants were enrolled and underwent a comprehensive periodontal examination, along with the collection of unstimulated saliva and venous blood for biochemical analyses. Before statistical analyses, participants were classified according to the 2018 periodontal classification as gingivitis, Stage 1/2 periodontitis, or Stage 3/4 periodontitis.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Having at least 20 natural teeth. * Diagnosis of cardiovascular disease confirmed by coronary angiography. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Fewer than 20 natural teeth. * Pregnancy or lactation. * Periodontal treatment within the previous 6 months. * Antibiotic or anti-inflammatory drug use within the previous 3 months. * Presence of systemic inflammatory, autoimmune, or infectious diseases that could affect periodontal inflammation. * History of malignancy. * Requirement for antibiotic prophylaxis before periodontal examination. * Refusal or inability to provide saliva or blood samples. * Having a history of COVID-19 infection where less than 2 months had elapsed since the last positive RT-PCR test result

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular disease Periodontal disease

Contacts and locations

Locations

  • Süleyman Demirel University

    Isparta, Merkez, 32200, Turkey (Türkiye)

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