Saliva test may uncover hidden gum disease in heart patients

NCT ID NCT07721428

Completed Knowledge-focused Sponsor: Suleyman Demirel University Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This observational study investigates whether levels of certain enzymes (ACE and ACE2) in saliva and blood are linked to the severity of gum disease in adults with cardiovascular disease. Researchers will compare these enzyme levels across different stages of gum disease—from gingivitis to advanced periodontitis—in 76 participants. The goal is to better understand the biological connection between oral health and heart health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If a link is found, it could point toward new ways to detect or monitor gum disease in people with heart conditions using simple saliva tests.
What could go wrong: This is an observational study, not a treatment trial, so it cannot prove cause and effect. Results may not apply to people without heart disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE PERIODONTAL DISEASE

Contacts and locations

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Locations

Süleyman Demirel University

Isparta, Merkez, 32200, Turkey (Türkiye)

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