Can Low-Dose combo tame tough blood pressure in kidney disease?

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the drugs alone or together for up to 12 weeks. The goal is to find effective treatment options that manage blood pressure without causing dangerous side effects like high potassium levels.