Could umbilical cord stem cells help failing kidneys?

NCT ID NCT07240987

Not yet recruiting Disease control Sponsor: The First Affiliated Hospital of Air Force Medicial University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests whether a single intravenous infusion of stem cells from donated umbilical cord tissue can safely improve kidney function in 32 adults with stage 3 or 4 chronic kidney disease caused by diabetes or high blood pressure. Participants will be randomly assigned to receive either the stem cells or a placebo (salt water) and will be followed for one year. The main goal is to see if the treatment can raise the kidney's filtration rate and reduce protein in the urine, which are signs of better kidney health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: umbilical cord mesenchymal stem cells (MSCs)
What this could lead to: If it works, this could point toward a new way to slow or partly reverse kidney decline in chronic kidney disease, potentially delaying the need for dialysis or transplant.
What could go wrong: This is a very early (Phase 1/2) and small (32 people) trial, so results may not be conclusive. Stem cell infusions carry risks like allergic reactions or infection, and the treatment may not improve kidney function.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome diabetic kidney disease hypertensive nephropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC KIDNEY DISEASE (DKD) HYPERTENSIVE NEPHROPATHY KIDNEY DISEASE, CHRONIC

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