New vitamin d pill aims to tame parathyroid glands in dialysis patients

NCT ID NCT03602261

Terminated Disease control Sponsor: OPKO Health, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 study tested a weekly extended-release capsule of calcifediol (CTAP101) in 44 adults with chronic kidney disease on hemodialysis who also had vitamin D insufficiency and secondary hyperparathyroidism. The goal was to see if the drug could raise vitamin D levels and lower parathyroid hormone. The trial was terminated early, so results are incomplete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Calcifediol (CTAP101) extended-release capsules
What this could lead to: If successful, this could offer a new treatment option to manage secondary hyperparathyroidism in kidney disease patients on dialysis.
What could go wrong: This was a small, early-phase trial that was terminated, so results are limited. The treatment may not prove effective or safe in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome end stage renal failure secondary hyperparathyroidism of renal origin vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASES SECONDARY HYPERPARATHYROIDISM DUE TO RENAL CAUSES STAGE 5 CHRONIC KIDNEY DISEASE VITAMIN D DEFICIENCY

Contacts and locations

Locations

AKDHC Medical Research Services

Peoria, Arizona, 85381, United States
AKDHC Medical Research Services

Phoenix, Arizona, 85027, United States
AKDHC Medical Research Services

Phoenix, Arizona, 85035, United States
AKDHC Medical Research Services

Phoenix, Arizona, 85258, United States
California Institute of Renal Research CKD/Dialysis & Transplant Division

La Mesa, California, 91942, United States
Hacienda Dialysis Center

Hacienda Heights, California, 91745, United States
Kidney & Hypertension Specialists

San Antonio, Texas, 78207, United States
Laurel Canyon Dialysis, LLC

Sun Valley, California, 91352, United States
Long Beach Quest Dialysis Center

Long Beach, California, 90807, United States
North America Research Institute, Inc.

San Dimas, California, 91773, United States
Northshore University Health

Evanston, Illinois, 60201, United States
Ontario Dialysis Center

Ontario, California, 91762, United States
Renal and Transplant Associates of New England

Springfield, Massachusetts, 01107, United States
Research by Design, LLC

Chicago, Illinois, 60643, United States
Southwest Houston Research LTD

Houston, Texas, 77099, United States
Southwest MS Nephrology

McComb, Mississippi, 39601, United States
University of Colorado Denver Anschutz Medical Campus

Aurora, Colorado, 80045, United States
WCCT Global, Inc.

Cypress, California, 90630, United States

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