New drug may scratch the itch for dialysis patients

NCT ID NCT05075408

Completed Symptom relief Sponsor: Galderma R&D Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called nemolizumab to see if it can reduce severe itching in adults with chronic kidney disease who are on dialysis. 258 participants received either nemolizumab or a placebo as injections every 4 weeks for 12 weeks. The main goal was to see how many people had a meaningful improvement in their worst itch score.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nemolizumab
What this could lead to: If it works, this could provide a new treatment to ease severe itching in people with kidney disease on dialysis.
What could go wrong: This is a combined Phase 2/3 trial with 258 participants, so results are still early. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic renal failure syndrome end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE ASSOCIATED MODERATE TO SEVERE PRURITUS

Contacts and locations

Locations

Galderma Investigational Site 5171

Madrid, 28040, Spain
Galderma Investigational Site 5580

L'Hospitalet de Llobregat, 08097, Spain
Galderma Investigational Site 6190

Madrid, 28046, Spain
Galderma Investigational Site 6278

Manises, 46940, Spain
Galderma Investigational Site 6292

Córdoba, 14004, Spain
Galderma Investigational Site 6293

Olkusz, 32-300, Poland
Galderma Investigational Site 6294

Brodnica, 87-300, Poland
Galderma Investigational Site 6295

Seville, 41009, Spain
Galderma Investigational Site 6296

Lodz, 90-153, Poland
Galderma Investigational Site 6297

Wroclaw, 50-556, Poland
Galderma Investigational Site 6298

Szombathely, 9700, Hungary
Galderma Investigational Site 6301

Budapest, 1076, Hungary
Galderma Investigational Site 6304

Kecskemét, 6000, Hungary
Galderma Investigational Site 6305

Miskolc, 3526, Hungary
Galderma Investigational Site 6309

Alcobendas, 28108, Spain
Galderma Investigational Site 6310

Szentes, 6600, Hungary
Galderma Investigational Site 6311

Valencia, 46017, Spain
Galderma Investigational Site 7003

Whittier, California, 90603, United States
Galderma Investigational Site 7004

Tampa, Florida, 33603, United States
Galderma Investigational Site 7007

Winston-Salem, North Carolina, 27103, United States
Galderma Investigational Site 7010

San Antonio, Texas, 78258, United States
Galderma Investigational Site 7011

Houston, Texas, 77054, United States
Galderma Investigational Site 7015

La Palma, California, 90623, United States
Galderma Investigational Site 7017

Riverside, California, 92505, United States
Galderma Investigational Site 7018

Glendale, California, 91206, United States
Galderma Investigational Site 7019

The Woodlands, Texas, 77384, United States
Galderma Investigational Site 7020

Edina, Minnesota, 55435, United States
Galderma Investigational Site 7022

McKinney, Texas, 75069, United States
Galderma Investigational Site 7025

Tampa, Florida, 33603, United States
Galderma Investigational Site 7026

Hollywood, Florida, 33021, United States
Galderma Investigational Site 7027

Columbus, Georgia, 31904, United States
Galderma Investigational Site 7028

Victorville, California, 92392, United States
Galderma Investigational Site 7032

Sanford, Florida, 32771, United States
Galderma Investigational Site 7035

Kansas City, Missouri, 64111, United States
Galderma Investigational Site 7037

Coral Gables, Florida, 33134, United States
Galderma Investigational Site 7038

Fresh Meadows, New York, 11365, United States
Galderma Investigational Site 7039

Arlington, Texas, 76015, United States
Galderma Investigational Site 7040

Dallas, Texas, 75231, United States
Galderma Investigational Site 9962

Las Vegas, Nevada, 89128, United States
Galderma Investigational Site 9963

Roseville, Michigan, 48066, United States
Galderma Investigational Site 9964

Victorville, California, 92394-1868, United States
Galderma Investigational Site 9965

Miami, Florida, 33125, United States
Galderma Investigational Site 9966

El Paso, Texas, 79925, United States
Galderma Investigational Site 9967

Chattanooga, Tennessee, 37404, United States
Galderma Investigational Site 9968

Norfolk, Virginia, 23502, United States
Galderma Investigational Site 9969

Wauwatosa, Wisconsin, 53226, United States
Galderma Investigational Site 9970

Boca Raton, Florida, 33421, United States
Galderma Investigational Site 9971

Denver, Colorado, 80230, United States
Galderma Investigational Site 9972

Wichita, Kansas, 67214, United States
Galderma Investigational Site 9973

Tarzana, California, 91356, United States
Galderma Investigational Site 9977

Greenville, Texas, 75402, United States
Galderma Investigational Site 9978

Lynwood, California, 90262, United States
Galderma Investigational Site 9980

Middlebury, Connecticut, 06762, United States
Galderma Investigational Site 9982

Minneapolis, Minnesota, 55404, United States
Galderma Investigational Site 9983

Overland Park, Kansas, 66210, United States
Galderma Investigational Site 9988

Bloomfield, Connecticut, 06002, United States
Galderma Investigational Site 9989

Bakersfield, California, 93309, United States
Galderma Investigational Site 9991

Glendale, California, 91205, United States
Galderma Investigational Site 9992

Roseburg, Oregon, 97471, United States
Galderma Investigational Site 9995

The Bronx, New York, 10461, United States
Galderma Investigational Site 9996

Los Angeles, California, 90048, United States
Galderma Investigational Site 9998

Great Neck, New York, 11021, United States
Galderma Investigational Site 9999

Spartanburg, South Carolina, 29306, United States
Galderma Investigational Site7016

Miami, Florida, 33155, United States

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