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Dialysis duel: does higher fluid volume or lower sodium improve patient outcomes?

NCT ID NCT07717255

Knowledge-focused Sponsor: East and North Hertfordshire NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This observational study looks at how different settings in haemodiafiltration (a type of dialysis) affect people with kidney failure. It compares high versus low fluid exchange volumes and two different sodium concentrations in the dialysis fluid. Researchers will track toxin removal, symptoms, cognitive function, nutrition, and fluid balance over a year to find the best approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help refine dialysis prescriptions to improve patient well-being and reduce complications.
What could go wrong
As an observational study, it cannot prove cause and effect. Results may not apply to all dialysis patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Nov 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients with ESKD receiving hemodialysis accross 5 dialysis units in East and North Hertfordshire NHS Trust , UK.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or above. * Ability to give informed consent. * End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months. * Prognosis \> 6 months as assessed by principal investigator (PI)

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Conditions

The condition(s) this trial relates to.

end stage renal failure Malnutrition nutritional deficiency disease nutritional disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid balance outcomes Haemodiafiltration Haemodialysis Malnutrition (calorie) Nutrition Patient reported outcome measurements

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Lister Hospital, East and North Hertfordshire NHS Trust

    RECRUITING

    Stevenage, Hertfordshire, SG1 4AB, United Kingdom

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