Breakthrough drug could open door to kidney transplants for 'Impossible' patients
NCT ID NCT04935177
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tested a drug called imlifidase in 64 highly sensitized kidney transplant patients who had almost no chance of finding a compatible donor. The drug breaks down harmful antibodies, allowing a transplant from a donor that would normally be rejected. The study measured kidney function at 12 months and found that imlifidase helped more patients receive a transplant with better kidney function compared to standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Imlifidase (a drug that breaks down antibodies to allow a kidney transplant)
What this could lead to
If successful, this could help highly sensitized patients get a kidney transplant they otherwise couldn't, improving kidney function and survival.
What could go wrong
This is a small, early-phase trial with only 64 participants. The drug may not work for everyone, and there are risks like infection or rejection.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner Health - University Medical Center - Phoenix
Phoenix, Arizona, 85006, United States
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Columbia University
New York, New York, 10032, United States
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Georgetown Transplant Institute
Washington D.C., District of Columbia, 20007, United States
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Hospital of the University of Pennsylvania, Penn Medicine
Philadelphia, Pennsylvania, 19104, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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John Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Keck Hospital of University of Southern California (USC)
Los Angeles, California, 90033, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic Phoenix
Phoenix, Arizona, 85054, United States
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Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Methodist Hospital Specialty and Transplant
San Antonio, Texas, 78229, United States
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New York University (NYU) Langone Transplant Institute, NYU Langone Health
New York, New York, 10016, United States
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New York-Presbyterian - Weill Cornell Medical Center
New York, New York, 10065, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Saint Barnabas Medical Center
Livingston, New Jersey, 07039, United States
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Sutter Health - California Pacific Medical Center
San Francisco, California, 94115, United States
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University of Alabama at Birmingham (UAB) Hospital
Birmingham, Alabama, 35249, United States
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University of California San Francisco (UCSF) Medical Center
San Francisco, California, 94143-0780, United States
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University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52242, United States
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University of Minnesota Medical School
Minneapolis, Minnesota, 55455, United States
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University of Washington Medical Center
Seattle, Washington, 98195, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States