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Breakthrough drug may give hope to kidney patients rejected for transplant

NCT ID NCT05369975

Completed Disease control Sponsor: Hansa Biopharma AB Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called imlifidase in 113 highly sensitized kidney patients who had a positive crossmatch against a deceased donor. The drug was given before transplant to reduce the risk of rejection. The main goal was to see how many patients still had a working kidney one year after transplant. Results were compared to less sensitized patients who did not receive the drug.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY TRANSPLANTATION IN HIGHLY SENSITIZED PATIENTS

Contacts and locations

Locations

  • Azienda Ospedaliera di Padova

    Padova, 35128, Italy

  • Azienda Ospedaliero - Universitaria di Parma

    Parma, 43100, Italy

  • CHU de Grenoble - Hôpital Michallon

    La Tronche, 38700, France

  • Centre Hospitalier Universitaire (CHU) de Rouen - Hôpital de Bois-Guillaume

    Bois-Guillaume, 76230, France

  • Charité - Universitätsmedizin Berlin

    Berlin, 13353, Germany

  • Department of Nephrology , Zaloška 7

    Ljubljana, 1000, Slovenia

  • Erasmus University Medical Center

    Rotterdam, 3015 GD, Netherlands

  • Hospital 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Clínic de Barcelona, Unidad de Trasplante Renal

    Barcelona, 08036, Spain

  • Hospital Del Mar, Servicio de Nefrología

    Barcelona, 08003, Spain

  • Hôpital Necker - Enfants Malades

    Paris, 75015, France

  • Institut klinicke a experimentalni mediciny (IKEM)

    Prague, 140-21, Czechia

  • Karolinska University Hospital

    Huddinge, 141 57, Sweden

  • Klinikum rechts der Isar der Technische Universitaet Muenchen

    Munich, 81675, Germany

  • Leicester General Hospital

    Leicester, LE5 4PW, United Kingdom

  • Leiden University Medical Center

    Leiden, 2333 ZA, Netherlands

  • Medizinische Universitaet Wien

    Vienna, 1090, Austria

  • St. James University Hospital

    Leeds, LS9 7TF, United Kingdom

  • UZ Leuven - Campus Gasthuisberg

    Leuven, 3000, Belgium

  • University Medical Center Groningen

    Groningen, 9713, Netherlands

  • Uppsala University Hospital

    Uppsala, 751 85, Sweden

  • Vall d'Hebron University Hospital (HUVH)

    Barcelona, Spain

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