Tiny study probes urea breakdown in dialysis patients

NCT ID NCT05076318

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from Aarhus University looked at how the urea cycle works in 10 people with end-stage kidney disease on dialysis. Participants received a 3-hour alanine infusion, and researchers measured urea production before and after dialysis. The goal was to understand urea cycle dysregulation, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

alanine infusion

What this could lead to

If successful, this could improve understanding of urea cycle problems in kidney failure, potentially guiding better dialysis or dietary management.

What could go wrong

This is a very small, early-stage observational study with only 10 participants, so results may not apply broadly. It is not testing a treatment, only measuring a biological process.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

end stage renal failure urea cycle disorder uremia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University Hospital Aarhus

    Aarhus N, 8200, Denmark