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Scientists use artificial gut to study kidney toxins

NCT ID NCT04768309

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how gut bacteria in people with chronic kidney disease (CKD) produce harmful toxins that build up in the body. Researchers collected stool samples from 20 patients with advanced CKD and placed them into an artificial intestine to test whether probiotics could reduce toxin production. The goal was to understand the process better, not to treat patients directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jun 2021

Finished

Jul 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 80 years old * Non diabetic (fasting blood glucose \<1.26 g / L, or lack of insulin or oral antidiabetic treatment) * BMI between 18 and 30 kg / m² * Patient with CKD stage 4-5 ( eDFG \< 30 ml/min/1.73m2 CKD-EPI) * Not dialyzed * No history of kidney transplant * Patient followed in the nephrology department of Pr FOUQUE at the Lyon Sud hospital center Exclusion Criteria: * Active inflammatory, infectious, cardiovascular or neoplastic disease * Colectomy, resection of the small intestine or cholecystectomy * Patient having received antibiotics, prebiotics, probiotics in the last 3 months. * Patient using laxatives (more than 2 doses per day for the last 3 months) * Known renal pathology or known urologic malformation (healthy volunteer only)

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Conditions

The condition(s) this trial relates to.

chronic kidney disease uremia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CKD UREMIA

Contacts and locations

Locations

  • Lyon Sud University Hospital

    Pierre-Bénite, Rhône, 69310, France

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