Could a triple therapy beat kidney muscle wasting?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * CKD Stage 5 patients receiving maintenance HD therapy for \>3 months * Oedema-free weight loss of at least 5% in 12 months or BMI less than 20 kg/m2 * Self-reported decreased physical function/muscle strength and appetite, increased fatigue * Male or female, aged \>18 years and * Able to provide written informed consent. Exclusion Criteria: * Under 18 years of age * Patients within 3 months of initiation of HD (patients in this time frame are generally less clinically stable, many having vascular access procedures performed and with much higher rates of intercurrent events, including death and hospitalisation) * Patients experiencing weight loss due to clinically explainable reasons for example malabsorption or oesophageal blockage * Patients already receiving chronic anticoagulation therapy or with a history of bleeding with 3 months/active bleeding issues * Patients receiving immunosuppressants or immunomodulators * Patients who are pregnant or breast feeding * Patients with a hypersensitivity to any of the constituent components of the omega-3 dietary supplement * Patients who have dementia, a psychiatric disorder (who are not treated and stable) or a severe cognitive impairment which would deem them unable to give informed consent * Patients with expected survival on dialysis of \<6 months \[e.g. those with severe heart failure (New York Heart Association ≥3)\] * Patients for whom dialysis withdrawal is being considered * Patients likely to receive a live-donor transplant or transfer to peritoneal dialysis during the study duration * Patients with bilateral lower limb amputations * Patients deemed to be clinically unstable by their treating physician * Patients who are non-English speaking (not having the ability to provide informed consent, read and write English) * Patients who are currently enrolled in any study which involves exercise, fish oil/omega-3 or have been taking fish oil or omega-3 supplementation in the previous 3 months * Patients who are not able/willing to be involved.