New study aims to detect liver damage without needles

NCT ID NCT04612764

Ongoing Knowledge-focused Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether simple blood tests and special scans can detect liver scarring in people with urea cycle disorders. Researchers will enroll 62 participants across five U.S. centers. The goal is to find noninvasive ways to monitor liver health, avoiding the need for liver biopsies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better, safer ways to monitor liver health in people with urea cycle disorders, reducing the need for invasive biopsies.
What could go wrong: This is an observational study, not testing a treatment. It may not find clear links between the tests and liver damage, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ARGI DEFICIENCY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

arginase deficiency argininosuccinic aciduria citrullinemia citrullinemia type I liver disorder ornithine carbamoyltransferase deficiency urea cycle disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARGI DEFICIENCY ARGININOSUCCINIC ACIDURIA ASL DEFICIENCY ASS DEFICIENCY CITRULLINEMIA 1 HYPERARGININEMIA ORNITHINE TRANSCARBAMYLASE DEFICIENCY UREA CYCLE DISORDER

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.