New drug aims to tame parathyroid glands in dialysis patients

NCT ID NCT05836220

Completed Disease control Sponsor: Pathalys Pharma Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). Participants received either PLS240 or a placebo intravenously three times a week for 27 weeks, followed by an open-label phase where all could receive PLS240. The main goal was to see if PLS240 could lower parathyroid hormone levels by at least 30%.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PLS240 (a drug given intravenously three times a week)
What this could lead to: If successful, PLS240 could offer a new treatment option to better control secondary hyperparathyroidism in people on dialysis, potentially reducing complications.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug requires frequent IV dosing, and side effects or limited effectiveness compared to existing treatments remain possible.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure secondary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END STAGE KIDNEY DISEASE SECONDARY HYPERPARATHYROIDISM

Contacts and locations

Locations

Site Number: BGR001-2

Gabrovo, 5300, Bulgaria
Site Number: BGR002-2

Rousse, 7002, Bulgaria
Site Number: BGR003-2

Lom, Montana, 3600, Bulgaria
Site Number: BGR004-2

Varna, 9000, Bulgaria
Site Number: ESP003-2

Córdoba, Cordoba, 14004, Spain
Site Number: ESP005-2

Manises, Valencia, 46940, Spain
Site Number: POL001-2

Lodz, Lódzkie, 90-242, Poland
Site Number: POL002-2

Poznan, Greater Poland Voivodeship, 60-214, Poland
Site Number: POL004-2

Tomaszów Mazowiecki, Lódzkie, 97-200, Poland
Site Number: POL005-2

Warsaw, Masovian Voivodeship, 02-758, Poland
Site Number: PRT001-2

Carnaxide, 2790-134, Portugal
Site Number: PRT002-2

Covilha, Castelo Branco District, 6200-000, Portugal
Site Number: PRT003-2

Lisbon, 1250-203, Portugal
Site Number: SRB001-2

Kruševac, 37000, Serbia
Site Number: SRB002-2

Niš, 18000, Serbia
Site Number: SRB003-2

Belgrade, 11000, Serbia
Site Number: SRB004-2

Užice, 31000, Serbia
Site Number: SRB005-2

Belgrade, Belgrade, 11080, Serbia
Site Number: USA001-2

Chula Vista, California, 91910-3813, United States
Site Number: USA002-2

Hollywood, Florida, 33024-2776, United States
Site Number: USA003-2

San Diego, California, 92111-3636, United States
Site Number: USA004-2

Fort Myers, Florida, 33908-4154, United States
Site Number: USA005-2

La Mesa, California, 91942-3017, United States
Site Number: USA006-2

Waxahachie, Texas, 75165-1399, United States
Site Number: USA007-2

Amherst, New York, 14228-2792, United States
Site Number: USA008-2

San Antonio, Texas, 78251-4125, United States
Site Number: USA009-2

Toledo, Ohio, 43606-1171, United States
Site Number: USA010-2

Greenville, South Carolina, 29605-4019, United States
Site Number: USA011-2

El Paso, Texas, 79925-4828, United States
Site Number: USA012-2

San Antonio, Texas, 78221-3019, United States
Site Number: USA013-2

Columbus, Georgia, 31904-3603, United States
Site Number: USA015-2

Newark, Delaware, 19713-2081, United States
Site Number: USA016-2

Minneapolis, Minnesota, 55404-1212, United States
Site Number: USA017-2

Middlebury, Connecticut, 06762-2843, United States
Site Number: USA018-2

San Dimas, California, 91773-3539, United States
Site Number: USA019-2

Granada Hills, California, 91344-7407, United States
Site Number: USA020-2

Escondido, California, 92025-4402, United States
Site Number: USA021-2

Tarzana, California, 91356-3647, United States
Site Number: USA022-2

Moorpark, California, 93021-3352, United States
Site Number: USA023-2

Arvada, Colorado, 80002-3714, United States
Site Number: USA024-2

Wichita, Kansas, 67214-2944, United States
Site Number: USA025-2

Kalamazoo, Michigan, 49007-3889, United States
Site Number: USA026-2

Durham, North Carolina, 27704-2147, United States
Site Number: USA027-2

Knoxville, Tennessee, 37923-3624, United States
Site Number: USA028-2

Mishawaka, Indiana, 46545-3519, United States
Site Number: USA029-2

Live Oak, Texas, 78233-4767, United States
Site Number: USA030-2

Los Angeles, California, 90022-4302, United States
Site Number: USA031-2

Aurora, Colorado, 80045-7202, United States
Site Number: USA033-2

Northridge, California, 91324-3528, United States
Site Number: USA034-2

Fullerton, California, 92832-3037, United States
Site Number: USA035-2

South Miami, Florida, 33143-5522, United States
Site Number: USA037-2

Norfolk, Virginia, 23507-1901, United States
Site Number: USA038-2

St. George, Utah, 84790-5898, United States
Site Number: USA039-2

Anaheim, California, 92801-6731, United States
Site Number: USA041-2

Orlando, Florida, 32801, United States
Site Number: USA042-2

Fresno, California, 93720-3389, United States
Site Number: USA043-2

Los Angeles, California, 90033, United States
Site Number: USA044-2

Lancaster, California, 93534-2831, United States
Site Number: USA045-2

Roseburg, Oregon, 97471-6214, United States
Site Number: USA046-2

Glendale, California, 91205-3313, United States
Site Number: USA048-2

Detroit, Michigan, 48236-2169, United States
Site Number: USA049-2

Northridge, California, 91324-2927, United States
Site Number: USA051-2

Fairfax, Virginia, 22033-1907, United States
Site Number: USA052-2

Victorville, California, 92395-8322, United States
Site Number: USA053-2

Charlotte, North Carolina, 28208-3876, United States
Site Number: USA054-2

New Orleans, Louisiana, 70112, United States
Site Number: USA055-2

Prosper, Texas, 75078-1411, United States
Site Number: USA056-2

Tarzana, California, 91356-2806, United States

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