Pee power: urine test may spare kids painful kidney biopsies
NCT ID NCT03719339
First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times
Summary
This study is testing whether a simple urine test can detect signs of kidney transplant rejection in children. Researchers are looking for specific molecules in urine that signal the body is attacking the new kidney. If the test works, it could help doctors spot problems early without needing a needle biopsy. The study involves 445 children aged 2 to 18 who have had a kidney transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a non-invasive urine test to monitor kidney transplant health in children, replacing some painful biopsies.
- What could go wrong
- This is an observational study, not a treatment trial. The urine test may not be accurate enough to replace biopsies, and results may not apply to all children.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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CHOP
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010-291, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Joan & Sanford I. Weill Medical College of Cornelle University
New York, New York, 10065-4805, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Stanford University
Palo Alto, California, 94304, United States
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University of California
Los Angeles, California, 90095, United States
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University of California-San Diego, Rady Children's Hospital
La Jolla, California, 92093-0894, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Vancouver Children's Hospital
Vancouver, British Columbia, V6T 1Z3, Canada
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