Kidney transplant breakthrough: Biopsy-Guided drug adjustments could save grafts

NCT ID NCT02444429

Completed Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a routine biopsy three months after kidney transplantation can help doctors adjust immunosuppressive drugs to prevent graft loss and reduce side effects. 346 patients were split into two groups: those with mild inflammation received extra steroids, while those without inflammation had their steroids reduced. The goal was to see if these tailored approaches improve kidney function and reduce damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Corticosteroid boluses (methylprednisolone) and corticosteroid withdrawal
What this could lead to: If successful, this could lead to better long-term kidney transplant survival and fewer side effects from immunosuppressants.
What could go wrong: This is a completed phase 3 trial, but results may not apply to all transplant patients. Risks include rejection or infection from changing immunosuppression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL TRANSPLANTATION

Contacts and locations

Locations

Département de Néphrologie et Transplantation d'Organes - Hôpital Rangueil - CHU de Toulouse

Toulouse, 31059, France
Institut de Transplantation, Urologie et Néphrologie (ITUN) - CHU de Nantes

Nantes, 44093, France
Service de Néphrologie - Hôpital Claude Huriez - CHU de Lille

Lille, 59037, France
Service de Néphrologie et Transplantation - Nouvel Hôpital Civil - CHRU Strasbourg

Strasbourg, 67091, France
Service de Néphrologie, Hémodialyse, Transplantations Rénales - Hôpital de la Cavale Blanche - CHU de Brest

Brest, 29609, France
Service de Néphrologie, Transplantation et Immunologie Clinique - Hôpital Edouard Herriot - Hospices Civils de Lyon

Lyon, 69437, France
Service de Néphrologie,Transplantation, Dialyse I - Hôpital Pellegrin - CHU Bordeaux

Bordeaux, 33000, France
Service de Transplantation - Hôpital Universitaire Necker

Paris, 75015, France

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