Blood test strategy may spare kidney patients from unnecessary biopsies

NCT ID NCT04774575

Completed Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using non-invasive blood biomarkers to guide when to perform a biopsy is as safe as doing routine biopsies at set times in kidney transplant recipients. 342 patients were randomly assigned to either a biomarker-guided group or a routine biopsy group. The goal was to see if the biomarker approach could reduce the number of biopsies without missing signs of organ rejection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: biomarker-guided strategy (non-invasive blood tests)
What this could lead to: If successful, this approach could reduce the need for painful and risky routine biopsies in kidney transplant patients, making follow-up safer and more comfortable.
What could go wrong: This is a completed trial, but the strategy may not detect all cases of rejection, and results may not apply to all transplant centers or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL TRANSPLANTATION

Contacts and locations

Locations

Bellvitge University Hospital

Barcelona, 08907, Spain
Charité-Universitätsmedizin,

Berlin, 10117, Germany
Charité-Universitätsmedizin, Berlin

Berlin, 10117, Germany
Geneva University Hospitals

Geneva, Canton of Geneva, 1205, Switzerland
Nantes Hospital

Nantes, 44000, France
Necker Hospital, Paris

Paris, Île-de-France Region, 75015, France
Saint-Louis Hospital, Paris

Paris, Île-de-France Region, 75010, France
Vall d'Hebron Hospital

Barcelona, 08035, Spain

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