New kidney drug could help kids with protein leak

NCT ID NCT05196035

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding finerenone to standard blood pressure medicines can reduce protein in the urine of children with chronic kidney disease. About 219 children aged 6 months to under 18 years will take either finerenone or a placebo for 6 months. The main goal is to see if the drug lowers urine protein levels more than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Finerenone (Kerendia)
What this could lead to: If it works, this could provide a new treatment option for children with chronic kidney disease to better control protein in the urine and slow kidney damage.
What could go wrong: This is still being tested in a relatively small group of children. It may not work better than existing treatments, and side effects like high potassium or low blood pressure are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome proteinuria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE PROTEINURIA

Contacts and locations

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Study contacts

Contact

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Contact

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Locations

A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica
COMPLETED

Torino, 10126, Italy
AKH Wien | Kinder & Jugendheilkunde, Kindernephrologie
COMPLETED

Vienna, Vorarlberg, 6800, Austria
Aarhus Universitetshospital - Børn og Unge
COMPLETED

Aarhus N, Central Jutland, 8200, Denmark
Alberta Children's Hospital | Nephrology Clinic
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
All India Institute of Medical Sciences (AIIMS) - New Delhi
RECRUITING

Delhi, National Capital Territory of Delhi, 110029, India
Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi
ACTIVE_NOT_RECRUITING

Florence, 50139, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria
COMPLETED

Bologna, Emilia-Romagna, 40138, Italy
Baskent Universitesi Tip Fakultesi Hastanesi
COMPLETED

Ankara, 6490, Turkey (Türkiye)
Birmingham Children's Hospital
NOT_YET_RECRUITING

Birmingham, West Midlands, B4 6NH, United Kingdom
Boston Children's Hospital - Main Campus - Nephrology
WITHDRAWN

Boston, Massachusetts, 02115, United States
CHC Montlégia - Pediatrics
COMPLETED

Liège, 4000, Belgium
CHU Strasbourg - Hopital Hautepierre
ACTIVE_NOT_RECRUITING

Strasbourg, Grand Est, 67200, France
CHU bordeaux - Hopital Pellegrin
COMPLETED

Bordeaux, New Aquitaine, 33076, France
CHU de Lyon - Hopital Femme Mère Enfant
COMPLETED

Bron, Auvergne-Rhône-Alpes, 69677, France
CU Saint-Luc/UZ St-Luc
COMPLETED

Bruxelles - Brussel, 1200, Belgium
Cedars-Sinai Medical Center - Nephrology
WITHDRAWN

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire Vaudois (CHUV)
COMPLETED

Lausanne, Canton of Vaud, 1012, Switzerland
Centre hospitalier universitaire Sainte-Justine | Cardiology
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Centro de Rehabilitacion Cardiovascular | San Luis, Argentina
COMPLETED

San Luis, San Luis Province, D5700CGR, Argentina
Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch
RECRUITING

Guishan, Taoyuan, 83301, Taiwan
Chang Gung Memorial Hospital at Linkou
RECRUITING

Taipei, 10507, Taiwan
Charité / Pädiatrie
COMPLETED

Berlin, 13353, Germany
Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department
ACTIVE_NOT_RECRUITING

Athens, 11527, Greece
Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department
ACTIVE_NOT_RECRUITING

Athens, 11526, Greece
Children's Hospital of Philadelphia - Nephrology
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Mercy Hospital Kansas City - Nephrology
RECRUITING

Kansas City, Missouri, 64108, United States
Children's National Hospital - Nephrology
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension
RECRUITING

Cincinnati, Ohio, 45229, United States
Clalit Health Services Schneider Children's Medical Center
COMPLETED

Petah Tikva, 4920235, Israel
Clalit Health | Soroka Medical Center- Nephrology Department
COMPLETED

Beersheba, 8410101, Israel
Cleveland Clinic | Pediatric Nephrology
RECRUITING

Cleveland, Ohio, 14013, United States
Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina
COMPLETED

Santa Fe, Santa Fe Province, S3000, Argentina
Cukurova Univ. Tip. Fak. Balcali Hastanesi
RECRUITING

Adana, 01790, Turkey (Türkiye)
Dana-Dwek Children's Hospital
COMPLETED

Tel Aviv, 6423906, Israel
Debreceni Egyetem Klinikai Kozpont
COMPLETED

Debrecen, Hajdú-Bihar, 4032, Hungary
Dzieciecy Szpital Kliniczny im. Jozefa Brudzinskiego
NOT_YET_RECRUITING

Warsaw, 02-091, Poland
Eccles Primary Children's Outpatient Services - Nephrology
RECRUITING

Salt Lake City, Utah, 84113, United States
Emory University Hospital/Children's Healthcare of Atlanta - Nephrology
WITHDRAWN

Atlanta, Georgia, 30322, United States
Fakultní nemocnice Motol a Homolka, Pracovište MOTOL
COMPLETED

Prague, Prague, 150 06, Czechia
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene
COMPLETED

Milan, Lombardy, 20122, Italy
Gazi Universitesi Tip Fakultesi
ACTIVE_NOT_RECRUITING

Ankara, 6560, Turkey (Türkiye)
Great Ormond Street Hospital for Children NHS Foundation Trust | Great Ormond Street Hospital - Clinical Research Facility
RECRUITING

London, Greater London, WC1N 3JH, United Kingdom
HUS-Yhtymä, Helsingin yliopistollinen sairaala (HUS) - Uusi lastensairaala, nefrologia
COMPLETED

Helsinki, Uusimaa, 00290, Finland
Hacettepe Universitesi Tip Fakultesi
COMPLETED

Ankara, 06230, Turkey (Türkiye)
Health Corporation of Galilee Medical Center
COMPLETED

Nahariya, 2210001, Israel
Hopital Arnaud de Villeneuve CHU Montpellier
COMPLETED

Montpellier, Occitanie, 34059, France
Hopital Robert Debre
COMPLETED

Paris, Île-de-France Region, 75019, France
Hopital des Enfants HUG
COMPLETED

Geneva, 1211, Switzerland
Hosp Clínicas Facult. Med. de Ribeirão Preto / USP
RECRUITING

Ribeirão Preto, São Paulo, 14051-140, Brazil
Hospital General de Ninos Pedro de Elizalde | Nephrology Department
COMPLETED

Buenos Aires, C1270, Argentina
Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department
ACTIVE_NOT_RECRUITING

Ciudad Autonoma de Buenos Aire, Ciudad Auton. de Buenos Aires, C1425EFD, Argentina
Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil
NOT_YET_RECRUITING

São Paulo, São Paulo, 01227-200, Brazil
Hospital Infantil de México "Dr. Federico Gómez"
WITHDRAWN

México D.F., Mexico City, 6720, Mexico
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas
RECRUITING

São Paulo, São Paulo, 13034-685, Brazil
Hospital Pequeno Principe
RECRUITING

Curitiba, Paraná, 80250-060, Brazil
Hospital Regional de Alta Especialidad Ixtapaluca
WITHDRAWN

Ixtapaluca, State of Mexico, 56530., Mexico
Hospital Sant Joan De Deu Barcelona | Nefrologia pediatrica
COMPLETED

Barcelona, 08950, Spain
Hospital Santa Maria | Centro de Investigacao Clinica
NOT_YET_RECRUITING

Lisbon, 1649-035, Portugal
Hospital Selayang
RECRUITING

Shah Alam, Selangor, 68100, Malaysia
Hospital Tuanku Ja'afar
RECRUITING

Seremban, Negeri Sembilan, 70300, Malaysia
Hospital Tunku Azizah
RECRUITING

Wilayah Persekutuan Putrajaya, Kuala Lumpur, 50300, Malaysia
Hospital Universitari Vall D Hebron | Nefrologia pediatrica
COMPLETED

Barcelona, 08035, Spain
Hospital Universitario 12 De Octubre | Nefrologia pediatrica
COMPLETED

Madrid, 28041, Spain
Hospital Universitario La Paz | Nefrologia pediatrica
COMPLETED

Madrid, 28046, Spain
Hospital Universitario Regional De Malaga | Nefrologia pediatrica
ACTIVE_NOT_RECRUITING

Málaga, 29010, Spain
Hospital Universitario Virgen Del Rocio S.L. | Nefrologia pediatrica
COMPLETED

Seville, 41013, Spain
Hospital Universiti Sains Malaysia
COMPLETED

Kelantan, Kelantan, 16150, Malaysia
Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia
WITHDRAWN

Nuevo León, Monterrey, 64460, Mexico
Hospital de Pediatría Juan P. Garrahan
WITHDRAWN

Buenos Aires, C1249ABN, Argentina
Hospital of LT University of Health Sciences Kaunas Clinics
COMPLETED

Kaunas, LT-50161, Lithuania
Huderf / Ukzkf
ACTIVE_NOT_RECRUITING

Bruxelles - Brussel, 1020, Belgium
Hôpital des Enfants
COMPLETED

Toulouse, Occitanie, 31059, France
IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene
COMPLETED

Genoa, Liguria, 16147, Italy
Institute of Kidney Diseases and Research Center Gujarat University of Transplantation Sciences
WITHDRAWN

Ahmedabad, Gujarat, 380016, India
Instituto Nacional de Pediatría
ACTIVE_NOT_RECRUITING

México, D.F., Mexico City, 4530, Mexico
Instituto Universitario Hospital Italiano de Buenos Aires | Hospital Italiano de Buenos Aires - Neurology Department
ACTIVE_NOT_RECRUITING

Ciudad Autonoma de Buenos Aire, Ciudad Auton. de Buenos Aires, C1199ABB, Argentina
Instituto Veracruzano en Investigación Clinica SC
ACTIVE_NOT_RECRUITING

Mexico City, Mexico City, 11850, Mexico
Instituto da Crianca e do Adolescente
RECRUITING

São Paulo, São Paulo, 05403 000, Brazil
Instytut "Pomnik - Centrum Zdrowia Dziecka"
COMPLETED

Warsaw, 04-730, Poland
Instytut Centrum Zdrowia Matki Polki
COMPLETED

Lodz, 93-338, Poland
Ippokratio General Hospital Of Thessaloniki-Pediatric Nephrology Unit, 3rd Department of Paediatrics
ACTIVE_NOT_RECRUITING

Thessaloniki, 54642, Greece
Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics
COMPLETED

Istanbul, 34093, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Kaohsiung Veterans General Hospital
NOT_YET_RECRUITING

Kaohsiung City, 813414, Taiwan
Karolinska University Hospital
ACTIVE_NOT_RECRUITING

Stockholm, Stockholm County, 141 86, Sweden
Kepler Universitätsklinikum Campus IV
COMPLETED

Innsbruck, Tyrol, 6020, Austria
Kindernierenzentrum Bonn
COMPLETED

Bonn, North Rhine-Westphalia, 53127, Germany
Klaipeda Children's Hospital
NOT_YET_RECRUITING

Klaipėda, LT-92140, Lithuania
Korea University Guro Hospital
COMPLETED

Seoul, Seoul Teugbyeolsi, 08308, South Korea
Kyungpook National University Hospital
COMPLETED

Daegu, 41944, South Korea
Lucille Packard Children's Hospital Stanford - Pediatric Nephrology
RECRUITING

Palo Alto, California, 94304, United States
MHAT prof. Stoyan Kirkovitch AD
WITHDRAWN

Stara Zagora, Stara Zagora Province, 6003, Bulgaria
Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility
RECRUITING

Manchester, Greater Manchester, M13 9WL, United Kingdom
Marmara University Medical Faculty | Pediatric Nephrology
COMPLETED

Istanbul, 34899, Turkey (Türkiye)
Mavani Kidney Care
RECRUITING

Ahmedabad, Gujarat, 380052, India
McMaster University Medical Centre | McMaster Children's Hospital | Cardiology
NOT_YET_RECRUITING

Hamilton, Ontario, L8N 3Z5, Canada
Medizinische Hochschule Hannover (MHH)
ACTIVE_NOT_RECRUITING

Hanover, Lower Saxony, 30625, Germany
Medizinische Univ Graz | Kinder & Jugendheilkunde
ACTIVE_NOT_RECRUITING

Graz, Styria, 8036, Austria
Memorial Transplant Institute - Pediatric Nephrology
RECRUITING

Hollywood, Florida, 33021, United States
Monash Children's Hospital
COMPLETED

Clayton, Victoria, 3168, Australia
NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility
RECRUITING

Glasgow, Scotland, G51 4TF, United Kingdom
NRS Medical college
COMPLETED

Kolkata, West Bengal, 700014, India
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
COMPLETED

Taipei, 100229, Taiwan
Nationwide Children's Hospital - Nephrology
NOT_YET_RECRUITING

Columbus, Ohio, 43205, United States
Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility
ACTIVE_NOT_RECRUITING

Nottingham, Nottinghamshire, NG7 2UH, United Kingdom
OBSOLETE_Uppsala University Hospital
TERMINATED

Uppsala, Uppsala County, 751 85, Sweden
OHSU Doernbecher Children's Hospital - Neurology
RECRUITING

Portland, Oregon, 97239, United States
Odense Universitetshospital - HC Andersen Børne og Ungehospital
COMPLETED

Odense, Region Syddanmark, 5000, Denmark
Ospedale Pediatrico Bambino Gesù - Nefrologia
COMPLETED

Rome, Lazio, 00165, Italy
Pecsi Tudomanyegyetem Klinikai Kozpont
COMPLETED

Pécs, Baranya, 7623, Hungary
Phoenix Children's Hospital | Main - Transplant Department
TERMINATED

Phoenix, Arizona, 85016, United States
Post Graduate Institute of Medical Education and Research
WITHDRAWN

Chandigarh, 160012, India
Pusan National University Yangsan Hospital
RECRUITING

Yangsan, Gyeongsangnam-do, 50612, South Korea
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 4101, Australia
Rigshospitalet - Børn og Unge
ACTIVE_NOT_RECRUITING

Copenhagen, Capital Region, 2100, Denmark
Royal Children's Hospital Melbourne
TERMINATED

Parkville, Victoria, 3052, Australia
SHATPD "Prof. Ivan Mitev"
NOT_YET_RECRUITING

Sofia, Sofia City Province, 1606, Bulgaria
Santa Casa de Misericórdia de Belo Horizonte
RECRUITING

São Paulo, São Paulo, 30150-221, Brazil
Seattle Children's Hospital - Nephrology
RECRUITING

Seattle, Washington, 98105, United States
Semmelweis University
COMPLETED

Budapest, 1083, Hungary
Seoul National University Bundang Hospital
COMPLETED

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Sitio Alfredo Chew Wong | Aguascalientes, Mexico
ACTIVE_NOT_RECRUITING

Aguascalientes, Agguascalientes, 20124, Mexico
Skånes Universitetssjukhus - Lund - Barnnefroenheten
COMPLETED

Lund, Skåne County, 221 85, Sweden
St. John's National Academy of Health Sciences
COMPLETED

Bengaluru, Karnataka, 560034, India
Sunway Medical Centre
RECRUITING

Subang Jaya, Selangor, 47500, Malaysia
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
ACTIVE_NOT_RECRUITING

Szeged, Csongrád-Csanád, 6720, Hungary
T.C. Saglik Bakanligi Ankara Bilkent Sehir Hastanesi Noroloji ve Ortopedi Hastanesi Noroloji Bolumu
COMPLETED

Ankara, 6800, Turkey (Türkiye)
Taipei Veterans General Hospital
ACTIVE_NOT_RECRUITING

Taipei, 11217, Taiwan
Tampere University Hospital, Tampereen yliopistollinen sairaala (TAYS) - Lasten lääketutkimuskeskus PeeTU
ACTIVE_NOT_RECRUITING

Tampere, Pirkanmaa, 33521, Finland
The Charlotte R. Bloomberg Children's Center Building - Nephrology
RECRUITING

Baltimore, Maryland, 21287, United States
The Children's Hospital at Westmead
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia
The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1X8, Canada
Turun yliopistollinen keskussairaala
ACTIVE_NOT_RECRUITING

Turku, Southwest Finland, 20520, Finland
UC San Diego - Altman Clinical and Translational Research Institute (ACTRI) - Linda Vista Clinic
RECRUITING

San Diego, California, 92023, United States
UMHAT Sveti Georgi
ACTIVE_NOT_RECRUITING

Plovdiv, Plovdiv Province, 4002, Bulgaria
UZ Gasthuisberg - Pediatric Nephrology
COMPLETED

Leuven, 3000, Belgium
UZ Gent
COMPLETED

Ghent, 9000, Belgium
Unidade Local de Saúde de Braga E.P.E. - Centro Clínico Académico de Braga - Serviço de Pediatria
NOT_YET_RECRUITING

Braga, 4710-243, Portugal
Unidade Local de Saúde de Coimbra, E.P.E. - Hospital Pediátrico - Serviço de Pediatria Ambulatória - Nefrologia
ACTIVE_NOT_RECRUITING

Coimbra, 3000, Portugal
Unidade Local de Saúde de Santo António, E.P.E
COMPLETED

Porto, 4050-651, Portugal
Uniklinikum Salzburg - Landeskrankenhaus
COMPLETED

Vienna, State of Vienna, 1090, Austria
Univ of Texas Health Science Center | Nephrology Res Dept
WITHDRAWN

San Antonio, Texas, 78207, United States
Universitair Medisch Centrum Groningen
COMPLETED

Groningen, 9713 GZ, Netherlands
Universitair Medisch Centrum St. Radboud
NOT_YET_RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands
University General Hospital Of Ioannina-Child Health Sector
COMPLETED

Ioannina, 45500, Greece
University General Hospital of Heraklion
COMPLETED

Heraklion, 71110, Greece
University Medical Center Utrecht
COMPLETED

Utrecht, 3584 CX, Netherlands
University of Iowa Health Care Medical Center - Nephrology
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States
Universitäts-Kinderspital UKBB
COMPLETED

Basel, Canton of Basel-City, 4031, Switzerland
Universitätsklinikum Erlangen AöR
NOT_YET_RECRUITING

Erlangen, Bavaria, 91054, Germany
Universitätsklinikum Essen
COMPLETED

Essen, North Rhine-Westphalia, 45147, Germany
Universitätsklinikum Hamburg Eppendorf (UKE)
COMPLETED

Hamburg, 20246, Germany
Universitätsklinikum Heidelberg
COMPLETED

Heidelberg, Baden-Wurttemberg, 69115, Germany
Universitätsklinikum Münster
COMPLETED

Münster, North Rhine-Westphalia, 48149, Germany
Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa
COMPLETED

Bialystok, 15-274, Poland
Uniwersytecki Szpital Dzieciecy w Krakowie
WITHDRAWN

Krakow, 30-663, Poland
Uniwersytecki Szpital Kliniczny UM we Wroclawiu
WITHDRAWN

Wroclaw, 50-556, Poland
Uniwersyteckie Centrum Kliniczne
COMPLETED

Gdansk, 80-952, Poland
Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre
COMPLETED

Vilnius, LT-08406, Lithuania
Všeobecná fakultní nemocnice v Praze
COMPLETED

Prague, Prague, 128 08, Czechia
Wilf Children's Hospital Shaare Zedek Medical Center
COMPLETED

Jerusalem, 9103102, Israel
Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit
RECRUITING

Soweto, Gauteng, 1862, South Africa

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