Could a thyroid pill boost heart health in dialysis patients?

NCT ID NCT03977207

Recruiting now Disease control Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether giving a thyroid hormone supplement (levothyroxine) to dialysis patients with mild hypothyroidism can improve their quality of life and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo for up to two years. The goal is to see if this common treatment actually helps this specific group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Levothyroxine (thyroid hormone supplement)
What this could lead to: If it works, this could point toward a safe way to improve quality of life and reduce heart disease risk in dialysis patients with mild hypothyroidism.
What could go wrong: This is a mid-sized trial, but the condition is mild and the benefits may be small. There is also a risk of overtreatment or side effects from thyroid hormone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

end stage renal failure hypothyroidism thyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMODIALYSIS HYPOTHYROIDISM THYROID; FUNCTIONAL DISTURBANCE

Contacts and locations

Locations

University of California Irvine
RECRUITING

Orange, California, 92868, United States

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