Can a pig thyroid extract tame hypothyroidism?

NCT ID NCT07747103

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This Phase 3 trial is testing an experimental tablet made from desiccated porcine thyroid extract, called North Star, in people with primary hypothyroidism. The study aims to see if this treatment can bring thyroid-stimulating hormone (TSH) levels into the normal range. Participants will take the extract and be monitored for safety and effectiveness over 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Desiccated porcine thyroid extract tablets (North Star)
What this could lead to
If successful, this could offer an alternative treatment option for people with primary hypothyroidism who need thyroid hormone replacement.
What could go wrong
This is an open-label, single-arm study, so results may be influenced by bias and lack a comparison group. The extract may not consistently control TSH levels or could cause side effects.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • 3Sync LLC

    NOT_YET_RECRUITING

    Miami Lakes, Florida, 33014, United States

  • 3Sync Research

    NOT_YET_RECRUITING

    Palm Springs, Florida, 33461, United States

  • Accel Research

    NOT_YET_RECRUITING

    Lakeland, Florida, 33803, United States

  • Accel Research

    NOT_YET_RECRUITING

    Largo, Florida, 33777, United States

  • ActivMed Practices and Research

    NOT_YET_RECRUITING

    Methuen, Massachusetts, 01844, United States

  • Advanced Medical Research Institute, LLC

    RECRUITING

    Miami, Florida, 33147, United States

  • Advanced Medical Trials, LLC

    NOT_YET_RECRUITING

    Georgetown, Texas, 78628, United States

  • AppleMed Research Group, LLC

    RECRUITING

    Miami, Florida, 33126, United States

  • Boston Clinical Trials

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02131, United States

  • Charlotteville Medical Research Center, LLC

    NOT_YET_RECRUITING

    Charlottesville, Virginia, 22911, United States

  • Coastal Carolina Research Center, LLC

    NOT_YET_RECRUITING

    North Charleston, South Carolina, 29405, United States

  • M3 Wake Research

    NOT_YET_RECRUITING

    Raleigh, North Carolina, 27612, United States

  • M3 Wake Research

    NOT_YET_RECRUITING

    Charleston, South Carolina, 29414, United States

  • M3 Wake Research

    NOT_YET_RECRUITING

    Chattanooga, Tennessee, 37421, United States

  • M3 Wake Research

    NOT_YET_RECRUITING

    Dallas, Texas, 75246, United States

  • M3 Wake Research - Las Vegas Wellness Way

    NOT_YET_RECRUITING

    Las Vegas, Nevada, 89106, United States

  • Olympus Clinical Research

    NOT_YET_RECRUITING

    Sugar Land, Texas, 77478, United States

  • Paradigm Clinical Research Centers, LLC

    NOT_YET_RECRUITING

    Modesto, California, 95355, United States

  • Paradigm Clinical Research Centers, LLC

    NOT_YET_RECRUITING

    Redding, California, 96001, United States

  • Paradigm Clinical Research Centers, LLC

    NOT_YET_RECRUITING

    San Diego, California, 92108, United States

  • Paradigm Clinical Research Centers, LLC

    NOT_YET_RECRUITING

    Aurora, Colorado, 80012, United States

  • Paradigm Clinical Research Centers, LLC

    NOT_YET_RECRUITING

    Boise, Idaho, 83709, United States

  • Precision Clinical Research

    NOT_YET_RECRUITING

    Sunrise, Florida, 33351, United States

  • Progressive Medicine of the Triad, LLC

    NOT_YET_RECRUITING

    Winston-Salem, North Carolina, 27103, United States

  • Sunwise Clinical Research

    NOT_YET_RECRUITING

    Walnut Creek, California, 94596, United States

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