HYPOTHYROIDISM

This study tests whether adding a second thyroid hormone (liothyronine) to the standard levothyroxine treatment can improve cholesterol levels and quality of life in people with hypothyroidism. About 90 adults with hypothyroidism will be randomly assigned to receive either standa…

This study looks at whether hypothyroidism caused by immune checkpoint inhibitors (a type of cancer immunotherapy) can go away after stopping the immunotherapy. 107 adult cancer patients who developed hypothyroidism during treatment and are now off immunotherapy will gradually re…

This study looks at whether older adults (65+) with hypothyroidism can safely take their thyroid medication (levothyroxine) with more flexible dosing. Researchers want to see if this affects quality of life, tiredness, and thinking skills. The trial involves 228 participants and …

This study tests a program to help doctors safely reduce or stop thyroid hormone medication in adults aged 65 and older who are getting too much or don't need it. The goal is to prevent harm from overtreatment while keeping thyroid levels healthy. About 900 participants will take…

This large study compares Armour Thyroid, a natural thyroid extract, to standard synthetic T4 (levothyroxine) in adults with primary hypothyroidism. About 2,800 participants who are stable on synthetic T4 will be randomly assigned to continue their current treatment or switch to …

This study tests whether giving a thyroid hormone supplement (levothyroxine) to dialysis patients with mild hypothyroidism can improve their quality of life and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo for up to two years. The go…

This study tests a decision support tool that uses blood samples from the first two weeks after thyroid surgery to predict the best levothyroxine dose. Normally, dose adjustments take months of trial and error. The trial will enroll 240 patients and compare the tool's guidance to…

This study compares two 12-week resistance training programs—nonlinear and linear periodization—to see which better improves quality of life in women with hypothyroidism. 75 women aged 35-45 with controlled hypothyroidism will participate. The goal is to find an exercise approach…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study is checking if thyroid problems (too much or too little thyroid hormone) change results of liver function tests. Researchers will measure bilirubin levels in 100 adults aged 20-60, comparing those with thyroid disease to healthy volunteers. The goal is to better unders…

This study looks at whether measuring a different thyroid hormone (fT3) or the ratio of two hormones (fT3/fT4) can give a clearer picture of thyroid health in people taking levothyroxine. It includes 500 adults with various types of hypothyroidism who are on a stable dose of the …