Could older thyroid patients get more flexible dosing?

NCT ID NCT06073665

Recruiting now Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether older adults (65+) with hypothyroidism can safely take their thyroid medication (levothyroxine) with more flexible dosing. Researchers want to see if this affects quality of life, tiredness, and thinking skills. The trial involves 228 participants and compares different dosing strategies over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Levothyroxine (thyroid hormone replacement)
What this could lead to: If successful, this could show that older adults with hypothyroidism can have more flexible dosing without harming their quality of life or thinking abilities.
What could go wrong: This is a Phase 4 trial with 228 participants, so results may not apply to everyone. There is a risk that flexible dosing could lead to under- or over-treatment of thyroid levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypothyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOTHYROIDISM

Contacts and locations

Locations

Penn Medicine, Smilow Translational Research Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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