Could a Two-Hormone combo beat standard thyroid treatment?

NCT ID NCT06731764

Recruiting now Disease control Sponsor: UConn Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a second thyroid hormone (liothyronine) to the standard levothyroxine treatment can improve cholesterol levels and quality of life in people with hypothyroidism. About 90 adults with hypothyroidism will be randomly assigned to receive either standard levothyroxine, or levothyroxine plus liothyronine taken once or twice daily. The goal is to find a safe and effective dosing regimen for future larger trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Levothyroxine and liothyronine (thyroid hormone combination therapy)
What this could lead to: If successful, this could point toward a more effective treatment for hypothyroidism that improves cholesterol levels and quality of life compared to standard levothyroxine alone.
What could go wrong: This is a small pilot study (90 people) that is still recruiting, so results may not apply to everyone. The combination therapy may not prove better than standard treatment and could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypothyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOTHYROIDISM

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

UConn Health
RECRUITING

Farmington, Connecticut, 06030, United States

Contact Email: •••••@•••••

Contact Email: •••••@•••••

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