Uconn Health

This study tests whether adding a second thyroid hormone (liothyronine) to the standard levothyroxine treatment can improve cholesterol levels and quality of life in people with hypothyroidism. About 90 adults with hypothyroidism will be randomly assigned to receive either standa…

This study tests two FDA-approved contrast agents, Gadopiclenol and Gadobutrol, to see which one makes pituitary lesions clearer on MRI scans. Ten adults with known or suspected pituitary lesions will each receive both agents in random order, and neither they nor the researchers …

This study tests whether a daily MitoQ supplement for 12 weeks can improve blood vessel function, walking speed, and thinking skills in frail older adults aged 65-80. Researchers will measure changes in blood flow, cognitive tests, and physical performance. The trial involves 60 …

This study compares two sperm collection timings—1 hour versus the usual 2-5 days of abstinence—to see which leads to more embryos with normal chromosomes during IVF. Researchers will track embryo health and pregnancy rates in 187 women. The goal is to find a simple way to improv…

This study aims to find the genes and genetic changes that cause craniometaphyseal dysplasia (CMD), a rare disorder that leads to abnormal bone growth in the skull and other bones. Researchers will analyze blood and tissue samples from 600 people, including affected individuals a…

This study aims to find the genes and genetic changes that cause aplasia cutis congenita (ACC), a rare condition where babies are born with missing patches of skin. Researchers will analyze DNA from 600 people with ACC and their family members. The goal is to better understand th…

This study aims to find the genes and DNA changes that cause cherubism, a rare condition that affects the jaw bones. Researchers will study blood and tissue samples from up to 600 people, including patients and their family members. The long-term goal is to understand the disease…

This study aims to find the genes that cause or contribute to keloid scarring. Researchers will analyze DNA from 7,000 people who have keloids, as well as their unaffected family members. The goal is to better understand why some people develop these raised scars, which could lea…

This study looks at whether doing a health program with a friend can change brain activity and drinking habits in young adults. About 248 participants will come in with a peer for a motivational interview, brain scan, and questionnaires, then be followed for a year. The goal is t…

This study looks at what happens when people with a certain type of heart failure (HFpEF) stop taking beta-blockers for 4 weeks. Researchers will measure changes in heart function, exercise ability, and quality of life in 30 participants. The goal is to see if stopping this commo…