Uconn Health

This study tests whether a combination of two thyroid medications (levothyroxine and liothyronine) works better than the standard single drug for people with hypothyroidism. The goal is to see if the combo can improve cholesterol levels and quality of life. Researchers will enrol…

This study tests whether a newer FDA-approved contrast agent, Gadopiclenol, provides clearer images of pituitary lesions on MRI compared to the standard agent, Gadobutrol. Ten adults with known or suspected pituitary lesions will receive both agents in random order, with neither …

This study tests whether computerized brain-training exercises can help older adults (age 60+) with Long COVID improve their thinking, mood, and daily life. Researchers will check if the program is easy to use and if people stick with it. The goal is to gather early evidence on w…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study aims to find the genes that cause aplasia cutis congenita (ACC), a rare condition where babies are born with missing patches of skin. Researchers will analyze DNA and tissue samples from 600 participants, including affected individuals and their family members. The goa…

This study looks at whether collecting sperm after just one hour of abstinence (instead of the usual 2-5 days) results in embryos with normal chromosomes during IVF. About 187 couples with infertility will each provide sperm after both short and standard abstinence, and the embry…

This study aims to find the genes that cause craniometaphyseal dysplasia (CMD), a rare bone disorder. Researchers will analyze blood and tissue samples from up to 600 people, including affected individuals and their family members. The goal is to understand the disease better and…

This study aims to find the genes that cause keloids, which are thick, raised scars that can grow beyond the original wound. Researchers will collect DNA from up to 7,000 people with keloids and their family members. The goal is to understand why some people get keloids and how t…

This study aims to find the genes and genetic changes that cause cherubism, a rare condition that affects the jaw bones. Researchers will study blood and tissue samples from up to 600 people, including patients and their family members. The long-term goal is to understand the dis…

This study looks at how young adults and their peers influence each other's brain activity and health behaviors. About 248 participants will complete questionnaires, take part in a health program with a friend, and have a brain scan. Researchers will follow up at 3, 6, and 12 mon…

This study looks at what happens when 30 people with a certain type of heart failure (HFpEF) stop taking their beta-blocker medication for 4 weeks. Researchers will measure changes in heart function, exercise ability, and quality of life. The goal is to learn whether stopping bet…