Could ditching Beta-Blockers improve heart function?

NCT ID NCT05174351

Recruiting now Knowledge-focused Sponsor: UConn Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at what happens when people with a certain type of heart failure (HFpEF) stop taking beta-blockers for 4 weeks. Researchers will measure changes in heart function, exercise ability, and quality of life in 30 participants. The goal is to see if stopping this common medication might actually be beneficial for these patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: beta blocker discontinuation
What this could lead to: If successful, this could suggest that some HFpEF patients may do better without beta-blockers, pointing toward a change in treatment guidelines.
What could go wrong: This is a very small pilot study with only 30 participants and no control group. Results may not apply to all HFpEF patients, and stopping beta-blockers could worsen symptoms in some individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH PRESERVED EJECTION FRACTION

Contacts and locations

Locations

UConn Health / John Dempsey Hospital
RECRUITING

Farmington, Connecticut, 06030, United States

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