New hope for kids on dialysis: drug targets overactive glands

NCT ID NCT03969329

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests the drug etelcalcetide (Parsabiv) in 24 children aged 2 to 17 with secondary hyperparathyroidism due to chronic kidney disease who are on hemodialysis. The goal is to see if the drug can safely lower parathyroid hormone levels and improve mineral balance. The study is open-label and everyone gets the drug, with no placebo group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

etelcalcetide (Parsabiv)

What this could lead to

If successful, this could provide a new treatment option to help control hormone levels and mineral balance in children with kidney disease on dialysis.

What could go wrong

This is a small, single-arm study with no placebo group, so results may be less reliable. Side effects like low calcium or gastrointestinal issues are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome secondary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SECONDARY HYPERPARATHYROIDISM

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Azienda Ospedaliera Universitaria Meyer
TERMINATED

Florence, 50139, Italy
Childrens Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos
TERMINATED

Vilinus, 08406, Lithuania
Fakultni nemocnice v Motole
COMPLETED

Prague, 150 06, Czechia
General Children Hospital Panagioti and Aglaias Kyriakou
RECRUITING

Athens, 11527, Greece
Great Ormond Street Hospital for Children
TERMINATED

London, WC1N 3JH, United Kingdom
Hopital Armand Trousseau
COMPLETED

Paris, 75012, France
Hospices Civils de Lyon Hopital Femme Mere Enfant
TERMINATED

Bron, 69677, France
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, Catalonia, 08035, Spain
Hospital Universitario Virgen del Rocio
TERMINATED

Seville, Andalusia, 41013, Spain
Ippokrateio General Hospital of Thessaloniki
RECRUITING

Thessaloniki, 54642, Greece
Kindernierenzentrum Bonn
COMPLETED

Bonn, 53127, Germany
Leeds Teaching Hospitals NHS Trust
RECRUITING

Leeds, LS1 3EX, United Kingdom
Medizinische Hochschule Hannover
COMPLETED

Hanover, 30625, Germany
Royal Hospital for Sick Children
RECRUITING

Glasgow, G51 4TF, United Kingdom
Semmelweis Egyetem
TERMINATED

Budapest, 1083, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar
TERMINATED

Szeged, 6720, Hungary
Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio
RECRUITING

Porto, 4050-651, Portugal
Universitaetsklinikum Hamburg Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Heidelberg, Zentrum fuer Kinder und Jugendmedizin
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Koeln
RECRUITING

Cologne, 50937, Germany
Universitair Ziekenhuis Gent
TERMINATED

Ghent, 9000, Belgium
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom
Uniwersytecki Szpital Dzieciecy w Krakowie
TERMINATED

Krakow, 30-663, Poland