New pill could help dialysis patients control dangerous phosphate levels

NCT ID NCT06712654

Recruiting now Disease control Sponsor: R1 Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 22, 2026 · Updated 9 times

Summary

This study tests a new drug called AP306 in 168 adults on maintenance hemodialysis who have high phosphate levels (hyperphosphatemia). Participants take one of several fixed doses of AP306 or a placebo daily for 8 weeks. The main goal is to see if AP306 safely lowers blood phosphate, a common and serious complication in kidney failure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AP306 (a drug taken by mouth to lower phosphate levels in the blood)
What this could lead to: If it works, this could offer a new treatment option to help control high phosphate levels in people on dialysis, potentially reducing related health risks.
What could go wrong: This is an early phase 2b trial with only 168 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

end stage renal failure hyperphosphatemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE REQUIRING CHRONIC DIALYSIS END STAGE RENAL DISEASE ON DIALYSIS HYPERPHOSPHATEMIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Academic Medical Research Institute
RECRUITING

Los Angeles, California, 90022, United States
Apogee Clinical Research, LLC
RECRUITING

Huntsville, Alabama, 35801, United States
California Institute of Renal Research
RECRUITING

Chula Vista, California, 91910, United States
Colorado Kidney Care
RECRUITING

Denver, Colorado, 80220, United States
DaVita Clinical Research
RECRUITING

Middlebury, Connecticut, 06762, United States
DaVita Clinical Research
RECRUITING

Las Vegas, Nevada, 89107, United States
DaVita Clinical Research
RECRUITING

Houston, Texas, 77054, United States
DaVita Clinical Research Edina
RECRUITING

Edina, Minnesota, 55435, United States
DaVita Clinical Research Norfolk
RECRUITING

Norfolk, Virginia, 23502, United States
DaVita Clinical Research San Antonio
RECRUITING

San Antonio, Texas, 78258, United States
Gamma Medical Research
RECRUITING

McAllen, Texas, 78503, United States
Johnson County Clinical Trials
RECRUITING

Kansas City, Missouri, 64111, United States
NY Kidney & Hypertension Medicine
RECRUITING

Ridgewood, New York, 11385, United States
Nephrology & Hypertension Specialists
RECRUITING

Dalton, Georgia, 30720, United States
North America Research Institute
RECRUITING

San Dimas, California, 91773, United States
PACT Kidney Care
RECRUITING

Orange, Connecticut, 06477, United States
R1 Therapeutics Clinical Trial Site
RECRUITING

Albuquerque, New Mexico, 87109, United States
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Waxahachie, Texas, 75165, United States
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100035, China
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100044, China
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Zhengzhou, Henan, 450003, China
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210003, China
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210009, China
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 201112, China
R1 Therapeutics Clinical Trial Site
NOT_YET_RECRUITING

Chengdu, Sichuan, 610072, China
St. Clair Nephrology Research
RECRUITING

Shelby, Michigan, 48315, United States
Sunbeam Research
RECRUITING

Greenville, Texas, 75402, United States
US Renal Care - Alexis
RECRUITING

Toledo, Ohio, 43613, United States
US Renal Care - Fort Myers South
RECRUITING

Fort Myers, Florida, 33912, United States
US Renal Care - South San Antonio
RECRUITING

San Antonio, Texas, 35801, United States
US Renal Care - Westover Hills
RECRUITING

San Antonio, Texas, 78251, United States

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