New hope for dialysis patients: drug AP301 targets dangerous phosphate levels

NCT ID NCT06933472

Recruiting now Disease control Sponsor: Alebund Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether AP301, a drug taken with meals, can safely lower high blood phosphate in people on kidney dialysis. About 264 participants will receive either AP301 or a low-dose version for 8 weeks, then all get AP301 for 24 weeks. The goal is to see if AP301 helps control phosphate levels and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AP301 (a phosphate binder taken orally with meals)
What this could lead to: If it works, AP301 could offer a new option to control high blood phosphate in dialysis patients, potentially improving their health and quality of life.
What could go wrong: This is a phase 3 trial, but the comparator is a low dose of AP301, not a placebo, which may limit how well we can judge effectiveness. Also, results may not apply to all dialysis patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome end stage renal failure hyperphosphatemia wild type ABeta2M amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE, RECEIVING DIALYSIS DIALYSIS ESRD (END STAGE RENAL DISEASE) HYPERPHOSPHATEMIA

Contacts and locations

Locations

Beijing Tsinghua Chang Gung Hospital
RECRUITING

Beijing, Beijing Municipality, 102218, China
Central South University-The Third Xiangya Hospital
RECRUITING

Changsha, Hunan, 410013, China
Children's Hospital of Fudan University
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200080, China
Dallas Renal Group - Dallas
RECRUITING

Dallas, Texas, 75237, United States
Fudan University-Huashan Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200040, China
Fudan University-Zhongshan Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Gamma Medical Research
RECRUITING

McAllen, Texas, 78503, United States
Henan Provincial People's Hospital
RECRUITING

Zhengzhou, Henan, 450003, China
High Desert Nephrology Association - US Renal Care
RECRUITING

Gallup, New Mexico, 87301, United States
Huazhong University of Science and Technology-Tongji Medical College - Wuhan Union Hospital
RECRUITING

Wuhan, Hubei, 430022, China
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
RECRUITING

Nanjing, Jiangsu, 210029, China
Jiangxi Provincial People's Hospital
RECRUITING

Nanchang, Jiangxi, 330006, China
NY Kidney & Hypertension Medicine
RECRUITING

Ridgewood, New York, 11385, United States
Nanjing Medical University-Wuxi People's Hospital (Wuxi No.1 People's Hospital)
RECRUITING

Wuxi, Jiangsu, 214023, China
Nantong University-Affiliated Hospital
RECRUITING

Nantong, Jiangsu, 226001, China
Nephrology & Hypertension Associates Ltd - Tupelo
RECRUITING

Tupelo, Mississippi, 38801, United States
Nephrology & Hypertension Specialists
RECRUITING

Dalton, Georgia, 30720, United States
Nephrology Associates, P.C. - Columbus
RECRUITING

Columbus, Mississippi, 38801, United States
North America Research Institute - San Dimas
RECRUITING

San Dimas, California, 91773, United States
North America Research Institute - San Dimas
RECRUITING

San Dimas, California, 91773, United States
PACT Kidney Care - Orange
RECRUITING

Orange, Connecticut, 06477, United States
Peking University First Hospital
RECRUITING

Beijing, Beijing Municipality, 100035, China
Peking University International Hospital
RECRUITING

Beijing, Beijing Municipality, 102218, China
Qingdao University-The Affiliated Hospital
RECRUITING

Qingdao, Shandong, 266000, China
Renal Associates Of Baton Rouge, LLC
RECRUITING

Baton Rouge, Louisiana, 70808, United States
Renal Consultants Medical Group
RECRUITING

Granada Hills, California, 91344, United States
Rocky Mountain Kidney Care - Lone Tree
RECRUITING

Lone Tree, Colorado, 80124, United States
Shanghai Jiao Tong University School of Medicine (SJTUSM)-Renji Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Shanghai Tongren Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200336, China
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, Sichuan, 610072, China
Southeast University-Zhongda Hospital
RECRUITING

Nanjing, Jiangsu, 210009, China
Subei People's Hospital
RECRUITING

Yangzhou, Jiangsu, 225002, China
The First Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, Fujian, 361003, China
US Renal Care - Alexis
RECRUITING

Toledo, Ohio, 43613, United States
US Renal Care - Bluebonnet
RECRUITING

Fort Worth, Texas, 76110, United States
US Renal Care - Fort Myers South
RECRUITING

Fort Myers, Florida, 33912, United States
US Renal Care - Hill Country
RECRUITING

San Antonio, Texas, 78251, United States
US Renal Care - South San Antonio
RECRUITING

San Antonio, Texas, 78211, United States
US Renal Care - West Cheektowaga
RECRUITING

Cheektowaga, New York, 14215, United States
Wuhan University People's Hospital
RECRUITING

Wuhan, Hubei, 430060, China
Yantai Yuhuangding Hospital
RECRUITING

Yantai, Shandong, 264099, China
Zhengzhou University-First Affiliated Hospital
RECRUITING

Zhengzhou, Henan, 450003, China

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