New combo pill aims to protect kidneys in High-Risk patients

NCT ID NCT07222917

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding dapagliflozin to baxdrostat reduces protein in the urine (a sign of kidney damage) better than baxdrostat alone. About 218 adults with chronic kidney disease and high blood pressure will take either the combo or baxdrostat plus a placebo. The goal is to see if the combination offers extra kidney protection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: baxdrostat and dapagliflozin
What this could lead to: If successful, this combination could offer a new way to reduce kidney damage in people with chronic kidney disease and high blood pressure.
What could go wrong: This is a phase IIb trial with only 218 participants, so results are preliminary. The added benefit of dapagliflozin over baxdrostat alone may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE AND HYPERTENSION

Contacts and locations

Locations

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Surprise, Arizona, 85374, United States
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Hollywood, Florida, 33021, United States
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Port Charlotte, Florida, 33952, United States
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Port Orange, Florida, 32127, United States
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Atlanta, Georgia, 30344, United States
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Champaign, Illinois, 61822, United States
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Wichita, Kansas, 67214, United States
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Eatontown, New Jersey, 07724, United States
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Greenville, North Carolina, 27834, United States
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Jacksonville, North Carolina, 28546, United States
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New Bern, North Carolina, 28562, United States
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Columbus, Ohio, 43215, United States
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Media, Pennsylvania, 19063, United States
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East Providence, Rhode Island, 02914, United States
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Arlington, Texas, 76015, United States
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Pasadena, Texas, 77504, United States
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San Antonio, Texas, 78212, United States
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Woodbridge, Virginia, 22192, United States
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Buenos Aires, C1060AAB, Argentina
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Ciudad de Buenos Aires, C1425AGC, Argentina
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Mar del Plata, 7600, Argentina
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Rosario, S2000CVD, Argentina
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San Nicolás, B2900DMH, Argentina
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Pernik, 2300, Bulgaria
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Plovdiv, 4004, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1680, Bulgaria
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Sofia, 1756, Bulgaria
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Sofia, 1756, Bulgaria
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Yambol, 8600, Bulgaria
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Courtice, Ontario, L1E 2J5, Canada
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Etobicoke, Ontario, M9W 6V1, Canada
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Stouffville, Ontario, L4A1H2, Canada
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Waterloo, Ontario, N2T 0C1, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Anyang-si, 14068, South Korea
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Cheonan-si, 31151, South Korea
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Goyang-si, 10380, South Korea
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Seoul, 04401, South Korea
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Badalona, 08916, Spain
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Pamplona, 31008, Spain
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Valencia, 46010, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 83301, Taiwan
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New Taipei City, 235, Taiwan
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Taichung, 402, Taiwan
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Taichung, 433004, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taoyuan, 333, Taiwan
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Bangkoknoi, 10700, Thailand
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Changwat Sara Buri, 18000, Thailand
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Hat Yai, 90110, Thailand
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Muang, 50200, Thailand
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Ratchathewi, 10400, Thailand
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Adana, 01060, Turkey (Türkiye)
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Adapazarı, 54290, Turkey (Türkiye)
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Kahramanmaraş, 46040, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Kyiv, 01601, Ukraine
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Kyiv, 02002, Ukraine
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Kyiv, 02091, Ukraine
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Kyiv, 03037, Ukraine
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Kyiv, 03049, Ukraine
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Kyiv, 04210, Ukraine
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Uzhhorod, 88018, Ukraine
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Vinnytsia, 21029, Ukraine
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Dundee, DD1 9SY, United Kingdom
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Liverpool, L9 7AL, United Kingdom
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London, E1 1FR, United Kingdom

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