Stem cell reset could open door to kidney transplants for 'Impossible' patients
NCT ID NCT07607197
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests whether a powerful immune reset using a patient's own stem cells can clear the antibodies that block them from receiving a kidney transplant. Ten highly sensitized adults with end-stage kidney disease will undergo intense conditioning to wipe out their immune memory, then receive their own purified stem cells to rebuild a naive immune system. The goal is to lower antibody levels enough to allow a compatible deceased-donor kidney transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Autologous hematopoietic stem cell transplantation (AHSCT) with conditioning drugs (rituximab, cyclophosphamide, thymoglobulin)
- What this could lead to
- If it works, this could allow highly sensitized patients to receive a compatible kidney transplant, reducing time on dialysis.
- What could go wrong
- This is a very early, small trial (10 people) testing an intense procedure with significant risks like infection and organ damage. The immune reset may not last or enable transplant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital Universitari Vall d'Hebron
RECRUITINGBarcelona, Catalonia, 08035, Spain
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Other studies related to the condition(s) this trial covers.
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