END STAGE LIVER DISEASE

This study looked at whether it is safe to transplant livers from deceased HIV-positive donors into HIV-positive recipients. Researchers followed 80 participants to track complications like graft failure, infections, and HIV breakthrough. The goal was to see if using HIV-positive…

This study tested whether livers from donors with hepatitis C could be safely transplanted into people without hepatitis C. Five patients on the liver transplant waiting list received these livers and were then treated with an antiviral drug to prevent infection. The goal was to …

This study looked at how the HIV drug raltegravir works in people with severe liver disease who need a liver transplant. It included 14 HIV-positive adults with end-stage liver failure. Researchers checked how the drug behaves in the body and how it interacts with anti-rejection …

This study tested whether multiple infusions of stem cells from donated umbilical cords could help people with end-stage liver disease. 92 adults received the stem cells through a vein, and researchers tracked liver function and complications. The goal was to see if repeated dose…

This study looked at whether donated livers that were not perfect (called extended criteria donor livers) could be safely used for transplant after being treated with a special machine that pumps fluids through them. The goal was to see if these livers would work well and last a …

This study tested whether giving growth hormone to people with decompensated liver cirrhosis (advanced liver scarring) could improve their health and survival. The trial included 96 adults with this condition. Researchers measured how long patients survived without major complica…

This study tested a device that pumps cold, oxygenated fluid through donor livers before transplant. The goal was to see if it reduces early organ damage in livers from older or higher-risk donors. 266 liver transplant patients took part. The approach could help more people get s…

This study tested whether an infusion of special immune cells (regulatory dendritic cells) from the donor could help liver transplant recipients safely reduce their anti-rejection medications. Sixteen low-risk patients received the cell infusion a week before transplant, then fol…

This study tested whether a nerve block called the external oblique intercostal plane block can reduce pain after liver transplant surgery. Sixty-four adult patients received either the block or a sham procedure after surgery. Researchers measured how much morphine patients neede…

This study tested two approaches to bring palliative care (comfort-focused care) to people with end-stage liver disease. About 1,500 adults from 19 U.S. centers took part. One group had direct access to a palliative care specialist; the other group saw a liver doctor specially tr…

This study looked at 446 liver transplant patients to see if changes in their MELD score (a measure of liver disease severity) could predict who might not survive. Researchers focused on patients with high MELD scores, who are at greater risk. The goal is to better understand how…

This study looked at how a new U.S. policy for distributing donated livers (started in 2020) affected costs for liver transplants at one hospital in Dallas. Researchers compared costs and transplant volumes for 186 patients before and after the policy change. The goal was to unde…

This study tested whether a non-invasive light sensor (near-infrared spectroscopy) placed on the skin over the kidney could measure oxygen levels during liver transplant surgery. Researchers monitored 41 patients to see if this method gives useful information about kidney functio…

This study looked at over 1,100 liver transplant patients to see if having a donor of a different gender affects long-term survival. Researchers followed patients for up to 10 years after transplant. The goal is to understand whether gender mismatch is a risk factor, which could …

This completed study looked at 300 liver transplant cases to understand why donor livers with fatty liver disease are more likely to be injured after transplantation. Researchers compared genetic activity in archived tissue samples from 50 cases, using advanced techniques to iden…

This pilot study tested a program called the Liver Live Donor Champion Program for people waiting for a liver transplant. The program trains a friend or family member to be an advocate and help the patient find a living donor. Researchers enrolled 76 liver transplant candidates a…

This study looked at 82 adults getting a liver transplant to see if using a special blood test called ROTEM helps doctors manage bleeding better than standard tests. The goal was to see if ROTEM could reduce the amount of blood products given during surgery. Researchers tracked c…

This study compared two surgical tools—surgical loupes (magnifying glasses) and a microscope—for repairing bile ducts during living donor liver transplants. 52 adults receiving a right-lobe liver graft with a single bile duct opening took part. The goal was to see which tool led …

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study from Mayo Clinic looked at 97 liver transplant patients to see how often they had lasting muscle weakness after surgery when given sugammadex, a drug to reverse anesthesia. Researchers used a device called TetraGraph to measure muscle response. The goal was to estimate…