New machine may help 'Marginal' donor livers work better after transplant

NCT ID NCT03929523

Completed Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a device that pumps cold, oxygenated fluid through donor livers before transplant. The goal was to see if it reduces early organ damage in livers from older or higher-risk donors. 266 liver transplant patients took part. The approach could help more people get successful transplants by improving the quality of donated organs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hypothermic Oxygenated Machine Perfusion (HOPE) device
What this could lead to: If it works, this could reduce early liver damage after transplant, helping more patients get successful transplants from older or higher-risk donors.
What could go wrong: This is a completed trial, but results may not apply to all transplant centers or donor types. The device adds time and complexity to the transplant process.

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Conditions

The condition(s) this trial relates to.

chronic liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER TRANSPLANTATION

Contacts and locations

Locations

APHP - Pitié Salpétrière

Paris, 75013, France
CHU Grenoble Alpes - Department of HPB surgery and liver transplantation

Grenoble, 38000, France
Department of HPB surgery and liver transplantation Beaujon University Hospital

Clichy, 92210, France
Department of HPB surgery and liver transplantation Claude Huriez University Hospital

Lille, 59037, France
Department of HPB surgery and liver transplantation Paul Brousse University Hospital

Villejuif, 94804, France
Department of HPB surgery and liver transplantation Pontchaillou University Hospital

Rennes, 35033, France
Hospices Civils de Lyon

Lyon, 69004, France
Hôpital Hautepierre - Department of HPB surgery and liver transplantation

Strasbourg, 67200, France

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