LIVER TRANSPLANTATION

This study tests whether giving liver transplant patients their immunosuppressive drugs as a single daily dose is as safe and effective as the standard twice-daily regimen. The goal is to make it easier for patients to stick to their lifelong medication, which may improve quality…

This study tests a method called normothermic machine perfusion, which keeps donated livers working outside the body so doctors can check if livers once considered too risky can still be used. About 186 adults on the liver transplant waiting list will be randomly assigned to eith…

This study tests whether treating donor livers with a special oxygen-rich cold fluid (HOPE) before transplant can lower the chance of liver cancer coming back. About 220 adults with liver cancer waiting for a transplant will be randomly assigned to receive either a standard prese…

This study tests two drugs, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure can cause dangerous bleeding, so finding the best drug may improve safety. About 50 adults …

This study looks at whether a structured Mediterranean diet can help people who have had a liver transplant avoid gaining too much weight and keep their new liver healthy. Researchers will track weight and body fat changes in 80 adults over time. The goal is to improve heart heal…

This study tests a way to help liver transplant recipients stop taking toxic anti-rejection drugs for good. Up to 12 adults who have had a living-donor liver transplant will receive a donor stem cell infusion after a mild conditioning treatment. The goal is to retrain the immune …

This study tests whether a medicine called tranexamic acid can reduce blood loss during adult liver transplant surgery. About 1,546 people will be randomly assigned to receive either the drug or a placebo. The main goal is to see if the drug works better than placebo at controlli…

This study looks at whether adding addiction counseling and monitoring after a liver transplant for alcohol-related liver disease can lower the chance of drinking again. About 720 adults who had a liver transplant for alcohol-related disease will be followed for two years. The go…

This study tests whether a bedside device called Quantra can help doctors manage bleeding during liver transplant surgery. The device measures blood clotting in real time to guide transfusion decisions. Researchers will compare this approach to standard care in 56 adults receivin…

This study tests whether giving extra albumin (a protein in the blood) after a liver transplant can prevent acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only g…

This study tests whether eating protein evenly throughout the day combined with exercise can improve nutrition, muscle mass, and physical function in 90 adults awaiting a liver transplant. Participants are split into three groups: even protein plus exercise, uneven protein plus e…

This study tests whether a nerve block called the external oblique intercostal plane block can reduce pain after liver transplant surgery. Sixty adults receiving a liver transplant will be split into two groups: one gets the nerve block plus standard care, the other gets standard…

This study tests if drinking a carbohydrate beverage before liver transplant surgery helps patients recover more quickly and spend fewer days in the hospital. About 434 adults receiving a liver transplant will be randomly assigned to drink either the carbohydrate drink or a place…

This study tests whether a special nerve block, given during surgery, can reduce pain and the need for morphine in people who donate part of their liver. 64 donors will be randomly assigned to receive either the nerve block plus standard pain medicine, or standard pain medicine a…

This study looks at how frailty, nutrition, muscle loss, and mental health affect people waiting for a liver transplant. Researchers will measure physical strength, walking ability, and daily function, along with diet and emotional well-being. The goal is to see which factors pre…

This study compares two fluid management strategies during liver transplant surgery to see which leads to better outcomes. About 138 adults with end-stage liver disease will take part. The main goal is to see if a larger study is possible by checking recruitment rates and how wel…

This study is for adults who have had a liver transplant and now have kidney issues. Researchers want to learn how often kidney function gets worse and what factors might cause that decline. They will look at results from kidney biopsies already done in the past 3 months. The goa…

This study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…