ACUTE KIDNEY INJURY

This study is testing if adding a drug called MEX-CD1 to dialysis fluid can safely remove excess iron from the blood of ICU patients with severe kidney failure caused by sepsis. Fourteen participants will receive two 24-hour dialysis sessions—one standard and one with the added d…

This study aims to find out if giving sodium bicarbonate (a common medication) to critically ill ICU patients who have both acute kidney injury and metabolic acidosis (too much acid in the blood) can improve their chances of survival and recovery 90 days later. It will enroll 660…

This study is testing whether giving amino acids (protein building blocks) through an IV drip can help prevent or reduce serious kidney injury in adults who are critically ill and on a heart-lung life support machine (ECMO). It will involve 40 patients across three hospitals, wit…

This study tests if giving fluids and a blood pressure medication (norepinephrine) together very early can prevent kidney injury in adults with septic shock. Septic shock is a life-threatening infection that can damage organs. Researchers will monitor 100 patients to see if this …

This study is testing whether N-Acetylcysteine, a medication also used for acetaminophen overdose, can protect kidney function in cancer patients receiving cisplatin chemotherapy. Researchers will measure kidney injury markers in blood and urine from 72 adult cancer patients who …

This study is testing whether using a special ultrasound scan (called VExUS) to guide how much fluid to give critically ill patients can help protect their kidneys. It will involve 100 adults in intensive care who have developed sudden kidney injury. Doctors will compare outcomes…

This study tests whether giving children an amino acid infusion during and after heart surgery can help prevent serious kidney injury and reduce time on a breathing machine. Researchers will compare the amino acid treatment to a placebo in 30 children at high risk for these compl…

This study is testing a new AI-powered tool designed to help emergency room doctors detect and manage sudden kidney injury (AKI) sooner. It will be used at three hospitals to see if it helps doctors make better decisions, avoid harmful medications, and improve patient outcomes. T…

This study is testing whether a new drug called QRX3 can slow down kidney function decline in people with chronic kidney disease. Researchers will give the drug to 3,000 participants who have gradually worsening kidney function to see if it helps preserve their kidneys better tha…

This study is testing if a drug called aminophylline can protect the kidneys of children receiving cisplatin chemotherapy. Cisplatin is effective against cancer but can cause serious kidney damage. Researchers will give aminophylline to some children alongside their chemo to see …

This study is testing a computer tool designed to predict which hospitalized children are at high risk for sudden kidney injury. The tool will run in the background of hospital systems, analyzing patient data to see if it can accurately flag kids who will develop kidney problems …

This study is testing a new scoring system called the STARZ score to see if it can predict kidney injury in newborns earlier than current blood tests. Researchers will follow 140 newborns in a hospital's intensive care unit to check if the score accurately identifies which babies…

This study aims to find better ways to detect kidney injury early in adults with sepsis, a life-threatening infection. Researchers will test if a special kidney ultrasound and a urine test can spot signs of kidney stress before standard blood tests show a problem. The goal is to …

This study aims to see if giving patients extra IV fluids during and after a heart procedure can prevent kidney damage. It will involve 290 adults with atrial fibrillation who are scheduled for a specific type of heart treatment called pulsed field ablation. Participants will be …

This study is testing if a short infusion of amino acids given during heart surgery can help prevent a common and serious complication called acute kidney injury. Researchers will compare two groups of adult patients having planned heart surgery: one group gets standard care, and…

This study tests a structured support program for family members who must decide whether to start emergency dialysis for a critically ill loved one with sudden kidney failure. It aims to see if the program improves the decision-making process and reduces family members' feelings …

This study aims to see if measuring a protein called uromodulin in the blood can help doctors predict how well a patient's kidneys will recover after a severe infection (sepsis) causes sudden kidney injury. Researchers will measure this protein in 30 adult patients with sepsis-re…

This study aims to see if a specific, guided method for giving fluids during heart surgery helps protect the kidneys from injury. It will compare this guided method to standard care in 100 adults having common heart operations. Researchers will measure special markers in the bloo…

This is a small pilot study to see if a special non-invasive monitor can work reliably during continuous dialysis for critically ill patients. The monitor checks blood levels and oxygen during treatment. Researchers want to know if the readings stay accurate over long periods and…

This study aims to see if two common blood tests, when used together, can help doctors predict which older patients with sepsis are most at risk for serious complications. Researchers will observe 80 patients aged 65 and older who are admitted to the ICU with sepsis. The goal is …

This study aims to understand if the amount of fluids a patient receives or loses in the first two days of intensive care is linked to developing sudden kidney injury. Researchers will closely monitor 120 critically ill adults who do not have kidney problems when they enter the I…

This international study aims to understand how continuous kidney dialysis (CRRT) is used in intensive care units worldwide. Researchers will observe 100,000 critically ill patients receiving this life-support treatment as part of their normal care. The goal is to document curren…

This study aims to create a risk prediction tool for emergency doctors. It will help identify which older adults (60+) who fall and remain on the floor for over an hour are at high risk for serious kidney problems or death. The tool will be developed by analyzing the medical reco…

This study is testing whether an AI assistant can help doctors make better decisions for critically ill patients in intensive care. About 1000 adult ICU patients will be randomly assigned to receive either standard care or care where doctors can see AI suggestions. Researchers wi…

This study aims to discover early warning signs for serious complications after heart surgery. Researchers will collect blood, voice recordings, and other data from 3000 patients to look for patterns that predict problems like kidney injury, delirium, or irregular heartbeat. The …