ACUTE KIDNEY INJURY

This study compares two FDA-approved antibiotic combinations to see which one is less likely to harm the kidneys in hospitalized adults with serious infections. About 852 participants will be randomly assigned to receive either vancomycin with piperacillin/tazobactam or vancomyci…

This study tests whether a newer blood thinner, nafamostat mesylate, works as well as the standard citrate during continuous kidney dialysis in people with sepsis-related kidney injury. About 1,162 adults will be randomly assigned to receive one of the two drugs. The main goal is…

This study tests whether giving amino acids (protein building blocks) through a vein can help prevent or reduce acute kidney injury in adults on ECMO life support. About 40 intensive care patients will receive either amino acids or a placebo. The goal is to see if this simple tre…

This study tests a new pre-mixed fluid that contains phosphate for ICU patients needing continuous kidney dialysis (CRRT). Standard fluids can wash out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the standard one in 220 adult…

This study tests if giving sodium bicarbonate (a common substance) to critically ill patients with metabolic acidosis and acute kidney injury can reduce serious kidney problems within 90 days. About 660 adults in intensive care will receive either sodium bicarbonate or a placebo.…

This study tests whether giving an amino acid infusion during and after heart surgery can lower the risk of acute kidney injury in children. About 30 children at high risk for kidney problems will receive either the amino acid or a placebo for up to 72 hours. Researchers will als…

This early-stage study tests whether adding the iron-binding drug MEX-CD1 to dialysis fluid can safely remove extra iron in adults with sepsis and acute kidney injury in the ICU. Fourteen participants will each receive two 24-hour dialysis sessions—one standard and one with the d…

This study looks at whether giving fluids and a blood-pressure-raising medicine (norepinephrine) early can prevent acute kidney injury in adults with septic shock. About 100 participants will receive this combined treatment in the ICU or emergency room. The goal is to see if this…

This study tests a new drug called QRX3 in 3000 people with chronic kidney disease (CKD) whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow further damage. Participants will take the drug and have their kidney function measured ove…

This study tests whether N-Acetylcysteine, a common drug, can protect kidney function in 72 adults with solid tumors who are receiving cisplatin-based chemotherapy. Participants will take either N-Acetylcysteine or a placebo for seven days around their chemo session. Researchers …

This study tests whether giving a short infusion of amino acids during heart surgery can help prevent acute kidney injury, a common complication. Researchers will measure kidney damage markers in the urine of 130 adult patients before and after surgery. The first group receives s…

This study tests a simple, non-invasive ear stimulation technique to prevent acute kidney injury—a common and serious complication after heart surgery using a heart-lung machine. About 152 adults scheduled for elective heart surgery will receive either the real stimulation or a s…

This study tests whether aminophylline, a drug usually used for asthma, can prevent kidney damage in children receiving cisplatin chemotherapy. About 24 children will be randomly assigned to receive either aminophylline or a placebo alongside their standard hydration protocol. Re…

This study will test whether an artificial intelligence (AI) tool, similar to ChatGPT-5, can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults will be randomly assigned to either standard care or care where doctors …

This study looks at whether a substance in the blood called uromodulin can help predict how well the kidneys will recover in adults with sepsis-related acute kidney injury. Researchers will measure uromodulin levels at the start of ICU care, after one week, and at discharge. The …

This study looks at whether the way you sleep before heart surgery is connected to your risk of confusion (delirium) and kidney injury after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to better understand t…

This study tests a structured program to help family members of ICU patients with acute kidney injury make decisions about starting dialysis. The program aims to reduce decision conflict, regret, anxiety, and depression. About 100 family members will be randomly assigned to recei…

This study aims to create a simple tool for emergency doctors to predict which older adults (60+) who fall and lie on the floor for over an hour are at risk of serious kidney problems or death. Researchers will review medical records of 1,000 patients to find key factors that lea…

This study looks at whether combining two blood markers—uric acid/albumin ratio and lactate—can help predict which older adults (65+) with sepsis will develop kidney injury, need blood pressure support, or die within 28 days. Researchers will follow 80 ICU patients without initia…

This study gathers data from up to 100,000 critically ill patients worldwide who receive continuous kidney dialysis (CRRT) in intensive care units. Researchers will analyze treatment patterns, patient outcomes, and differences between hospitals. The goal is to learn what works be…

This study watches 120 critically ill adults in the ICU to see if the amount of fluids they get in the first 48 hours is linked to acute kidney injury (AKI). Participants must not have kidney injury at the start. Doctors will track fluids, weights, and lab tests to see who develo…

This study looks at 3,000 adults having planned heart surgery to find out if things like genes, blood markers, and even voice recordings can help predict serious complications such as kidney injury, delirium, or bleeding. Researchers will collect samples and data before, during, …

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having bypass surgery will be enrolled. Researchers will measure kidney injury markers and track how much fluid is given, length of I…

This study will check if a new scoring system called STARZ can predict kidney injury in newborns within the first week of life. Researchers will enroll 140 babies in the NICU and compare the STARZ score to standard tests. The goal is to catch kidney problems early so doctors can …

This study looks at whether a special ultrasound technique called VExUS can help doctors manage fluids better in ICU patients with acute kidney injury. About 100 adults in intensive care will be observed and some will have their treatment guided by VExUS. The goal is to see if th…

This study looks at whether blood electrolyte levels are linked to kidney injury in people having a stroke procedure. Researchers will review records of 250 stroke patients to compare those who developed kidney problems with those who did not. The goal is to find new ways to pred…

This study looks at whether a simple ultrasound of the kidneys and a urine test can help doctors detect kidney injury early in people with sepsis. Researchers will follow 130 adults with sepsis to see if these tests can predict kidney problems before they become serious. The goal…