Can restarting blood pressure pills early after kidney injury be done safely?
NCT ID NCT07734636
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This pilot trial tests whether restarting renin-angiotensin system inhibitors (RASi) — common blood pressure and kidney-protecting medications — early after acute kidney injury is feasible and well-tolerated. Hospitalized adults who were on RASi before admission and stopped due to kidney injury are randomly assigned to early restart or usual care. The study tracks how many restart within 72 hours of kidney recovery signs and monitors safety through lab tests and 90-day follow-up.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- renin-angiotensin system inhibitors (RASi), such as ACE inhibitors or ARBs
- What this could lead to
- If early restart proves feasible and well-tolerated, it could guide safer management of these common medications after kidney injury.
- What could go wrong
- This is a small pilot trial with only 60 participants, so results may not apply broadly. Early restart could risk further kidney damage or high potassium levels.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California, San Francisco
San Francisco, California, 94143, United States
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