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Urine biomarkers may spot kidney damage before standard tests do

NCT ID NCT07704242

Knowledge-focused Sponsor: Medipol University Source: ClinicalTrials.gov ↗

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Cancelled before anyone took part.

Expanded access (not trials)

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When the status isn't known

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Status unknown
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First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This observational study looks at whether two urine markers, NGAL and KIM-1, can detect early kidney injury in women undergoing gynecologic laparoscopic surgery. The surgery involves gas inflation and a head-down position that can stress the kidneys. Researchers will compare these markers in patients positioned at 30° versus 45° head-down tilt to see if they reveal damage before standard blood tests do.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple urine test to catch kidney damage earlier during laparoscopic surgeries, potentially preventing serious injury.
What could go wrong
This is a small observational study, so results may not apply to all patients or surgeries. The biomarkers may not prove reliable enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult women undergoing elective gynecological laparoscopic surgery at a single tertiary care center. Eligible participants are those with an anticipated pneumoperitoneum duration of at least 90 minutes and a planned intraoperative Trendelenburg position of approximately 30° or 45°, according to routine surgical practice. Participants will be enrolled prospectively after providing written informed consent.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Female participants aged 18 years or older. Scheduled for elective gynecological laparoscopic surgery. Expected duration of pneumoperitoneum of at least 90 minutes. Planned intraoperative Trendelenburg position of approximately 30° or 45°. Ability to provide written informed consent. - Exclusion Criteria: Age younger than 18 years. Pre-existing chronic kidney disease (estimated glomerular filtration rate \<60 mL/min/1.73 m² or serum creatinine above the institutional upper limit of normal). Acute kidney injury before surgery. History of kidney transplantation or renal replacement therapy. Active urinary tract infection. Pregnancy. Conversion from laparoscopic to open surgery. Intraoperative conditions requiring major deviation from the standardized anesthetic or surgical protocol. Inability to provide written informed consent. \-

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Conditions

The condition(s) this trial relates to.

acute kidney injury Pneumoperitoneum

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Subclinical acute kidney injury

How to take part

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  1. The places running it

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  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Medipol Mega University Hospital

    Istanbul, Istanbul, 34214, Turkey (Türkiye)

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