Can baking soda save kidneys? new trial tests cheap treatment for ICU patients

NCT ID NCT07464431

Not yet recruiting Disease control Sponsor: Universität Münster Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a standard balanced fluid. The main goal is to see if fewer patients die, need dialysis, or have lasting kidney damage within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sodium bicarbonate
What this could lead to: If it works, this could provide a simple, low-cost treatment to reduce the risk of kidney failure or death in critically ill patients with acute kidney injury.
What could go wrong: This is a phase 4 trial, but previous evidence is limited to a subgroup analysis. The treatment may not show benefit, and sodium bicarbonate can cause side effects like fluid overload or electrolyte imbalances.

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Conditions

The condition(s) this trial relates to.

Acidosis acute kidney injury Critical Illness metabolic acidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY CRITICAL ILLNESS METABOLIC ACIDOSIS

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