ACUTE KIDNEY INJURY

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study tested whether giving sodium bicarbonate (a common substance that neutralizes acid) to critically ill patients with severe metabolic acidosis and moderate-to-severe acute kidney injury could improve survival at 90 days. The trial enrolled 640 adults in the ICU who had …

This study tested whether metformin, a common diabetes drug, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers gave low-dose metformin to 80 ICU patients with sepsis and kidney injury, monitoring for side effects and feasibility. The goal…

This study looked at 120 critically ill patients with acute kidney injury and shock who needed dialysis. Researchers compared a special method called sodium profiling dialysis to standard dialysis to see if it helped keep blood pressure stable and reduced fluid buildup in the lun…

This study tested a new way to monitor kidney oxygen levels during liver surgery to try to prevent acute kidney injury (AKI). 80 adults having liver surgery were randomly assigned to either standard care or extra monitoring that triggered a step-by-step treatment plan if oxygen l…

This study tested whether adding regional citrate anticoagulation (RCA) to standard heparin can reduce clotting in continuous kidney dialysis circuits for patients on ECMO. Eighteen ICU adults with ARDS and acute kidney injury were enrolled. Each patient received alternating peri…

This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal wa…

This study tested whether methylene blue, a dye that affects blood vessel function, can prevent dangerous drops in blood pressure during kidney dialysis. It involved 261 critically ill adults with acute kidney injury who needed dialysis. The goal was to see if the treatment could…

This study tested whether breathing in nitric oxide during and after heart surgery can prevent acute kidney injury. It included 250 adults with signs of blood vessel problems who were having long heart surgeries. Patients received either nitric oxide gas or a placebo (nitrogen) d…

This study looked at whether giving a single dose of gabapentin before laparoscopic sleeve gastrectomy (weight-loss surgery) helps protect kidney function in people with severe obesity. 90 patients with normal kidney function were enrolled. Researchers measured kidney markers lik…

This study looked at whether giving nitric oxide gas during and after surgery could lower the risk of acute kidney injury in people undergoing emergency repair of a torn aorta. 106 adults were randomly assigned to receive nitric oxide or a placebo. The main goal was to see how ma…

This study tested a new urine test (RENISCHEM L-FABP) to see if it can predict acute kidney injury within 2 days after heart or blood vessel procedures that use contrast dye. Researchers measured a kidney stress marker in 382 adults at higher risk. The goal was to validate the te…

This study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…

This study tested whether a fast removal of 250 ml of fluid during dialysis can predict which ICU patients with acute kidney injury are at risk of unstable blood pressure. Twenty adults on mechanical ventilation and continuous dialysis underwent two different speeds of fluid remo…

This study aims to create a better way to detect acute kidney injury early after heart surgery. Researchers will combine blood and urine tests with patient information to build a scoring system. The goal is to identify high-risk patients quickly so doctors can take steps to prote…

This study tested whether giving the acid-reducing drug pantoprazole during heart surgery could prevent acute kidney injury, a common complication. One hundred adults at moderate-to-high risk for kidney damage were randomly assigned to receive either pantoprazole or another acid …

This study tested whether giving activated vitamin D (calcifediol and calcitriol) to critically ill patients in the ICU could prevent or lessen acute kidney injury (AKI). Researchers enrolled 150 adults at high risk for AKI. The goal was to see if this treatment could reduce deat…

This study looked at 155 critically ill patients on ventilators to see if the difference between carbon dioxide in their breath and blood could predict acute kidney injury. Researchers measured this gap over the first 24 hours in the ICU. The goal was to find a simple, early warn…

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This completed study looked at 170 adults who needed emergency hemodialysis for acute kidney injury. Researchers measured three blood markers (Activin A, Nostrin, and Angiopoetin-2) before dialysis to see if they could predict whether the kidneys would recover or if the patient w…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This study looked at whether intentionally lowering blood pressure during nose surgeries (like rhinoplasty) might cause hidden kidney injury. Researchers measured two sensitive kidney biomarkers (NGAL and cystatin C) in 35 adults before and after surgery. The goal was to detect e…

This study looked at 1416 very sick adults in the ICU to see how well different stages of acute kidney injury (AKI) match the kidneys' actual ability to filter waste. Researchers used a urine test to measure kidney function and compared two common ways to diagnose AKI: one based …

This completed study looked at 211 people with sepsis, some of whom also had acute kidney injury. Researchers measured specific microRNAs and other markers in the blood to understand how kidney damage happens. The goal was to find new targets for diagnosis or treatment, not to te…

This study looked at whether giving antibiotics before a kidney drainage procedure (called percutaneous nephrostomy) prevents urinary tract infections in cancer patients whose urinary tract is blocked by a tumor. Researchers reviewed records of 320 cancer patients who had the pro…

This completed study looked at over 3,000 heart surgery patients who developed acute kidney injury. Researchers tested new biomarkers to see if they could predict which patients would get worse. The goal is to help doctors identify high-risk patients earlier and improve care.

This study looked at how a 10 km run and a 1.5 km swim affect kidney function in 40 healthy, active adults. Researchers used sensitive urine tests to detect subtle kidney changes that standard blood tests might miss. The goal was to better understand temporary kidney stress from …

This study looked at 174 older adults (ages 65-80) having lumbar fusion surgery to see whether using sodium acetate Ringer's solution or sodium lactate Ringer's solution during the operation better protects the kidneys. Researchers measured early kidney injury markers in urine an…

This completed study looked at whether a protein called vasorin in the blood can help predict how severe kidney injury will be in people with septic shock. Researchers took blood samples from 50 intensive care patients on day 0 and day 3. The goal was to see if vasorin levels are…

This study looked at over 5,000 critically ill children from hospitals worldwide to learn more about acute kidney injury (AKI). The goal was to better understand how common AKI is, what puts children at risk, and how to predict it using a tool called 'renal angina.' The study did…

This study measured certain proteins in the blood and urine of 20 newly diagnosed multiple myeloma patients before and 30 days after starting daratumumab. The goal was to see if these markers could help detect early kidney injury. Participants provided samples during routine lab …

This study looked back at 455 adults who had heart surgery with a heart-lung machine. Researchers wanted to see if routine blood tests and other factors before surgery could predict acute kidney injury, a serious complication. They found that certain markers of inflammation and k…

This study looked at 76 ICU patients with severe pneumonia who were placed on a lung machine (ECMO) and given minimal ventilator support. Researchers wanted to see if this approach changed how well the kidneys worked. They reviewed medical records from 2019 to 2023, comparing uri…

This study tested a prediction tool that uses routine lab results to estimate a patient's risk of kidney injury after heart surgery. Researchers looked at data from 2,500 adults who had heart surgery to see how well the tool worked. The goal is to help doctors catch kidney proble…

This study looked at whether taking ibuprofen before running in the heat increases signs of kidney injury. Twelve healthy adults took either ibuprofen or a placebo before running for an hour in a hot room. Researchers measured kidney injury markers in urine and blood before, righ…

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This study tested whether a machine learning model could predict kidney injury caused by platinum chemotherapy more accurately than doctors. Researchers followed 77 cancer patients receiving cisplatin or carboplatin, tracking their kidney function over time. The goal was to see i…

This study looked at nearly 6,000 ICU patients with severe kidney injury to see if a scoring tool called UNDERSCORE can predict when dialysis can be safely stopped. The goal was to avoid restarting dialysis or early death within 7 days. Researchers used existing hospital data to …

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their heart function related to their kidney problem. The goal was to impr…

This study looked at whether using dialysis less often helps people recover from acute kidney injury that requires dialysis. 220 hospitalized adults were assigned to either a conservative (less frequent) dialysis plan or the usual thrice-weekly schedule. The goal was to see if th…

This pilot study tested whether using ultrasound to check fluid tolerance is feasible in hospitalized patients with acute kidney injury (AKI). 80 non-ICU adults were randomly assigned to receive either standard care or an ultrasound-guided fluid assessment. The main goal was to s…

This study looked at 319 patients who needed dialysis for severe acute kidney injury. Researchers collected their medical information to identify risk factors for developing chronic kidney disease. The goal was to create a scoring system that helps doctors decide which patients w…

This study tested a new way to send alerts to doctors when a patient develops acute kidney injury (AKI). Instead of alerting for every case, the system used a model to identify which patients would benefit most from the alert. Over 2,000 adults with AKI in the hospital were inclu…

This study looked back at the medical records of 238 severely burned adults who needed continuous kidney therapy (CRRT) in the intensive care unit. The goal was to see how the timing of starting CRRT and the severity of kidney injury related to survival and how long patients stay…

This study looked at whether continuing or temporarily stopping the blood pressure medicine Ramipril (an ACE inhibitor) before coronary angiography affects the risk of kidney injury from the contrast dye. 44 adults were randomly assigned to either keep taking their usual dose or …

This study tested whether a computer system that alerts pharmacists about patients at risk for drug-related kidney injury can help doctors make safer medication decisions. The trial involved 698 hospitalized adults across eight hospitals. Pharmacists reviewed alerts and made reco…