ACUTE KIDNEY INJURY

This study tested whether stopping a common blood pressure medicine (Ramipril) before a heart artery scan reduces the risk of kidney damage from the dye used. 44 adults were randomly assigned to either stop the medicine 2 days before the scan or keep taking it. Researchers measur…

This study tested whether adding a special anticoagulant called citrate to the standard blood thinner (heparin) could prevent clotting in the kidney dialysis circuit during ECMO. 18 adults on ECMO for lung failure who also needed dialysis for kidney injury took part. The goal was…

This study tested if using a special light sensor to monitor kidney oxygen levels during liver surgery can help prevent acute kidney injury. Eighty adults having planned liver surgery were randomly assigned to standard care or care guided by this sensor. The goal was to see if re…

This study tested whether giving nitric oxide gas during surgery could lower the chance of acute kidney injury in people having emergency repair of a torn aorta (type A aortic dissection). 106 adults took part. The main goal was to see if fewer patients developed kidney problems …

This study tested whether two forms of activated vitamin D (calcifediol and calcitriol) could prevent or reduce the severity of acute kidney injury in critically ill patients. Researchers enrolled 150 adults in the ICU who were at high risk for kidney damage. The goal was to see …

This study looked at 60 critically ill patients with acute kidney injury and shock who needed dialysis. Researchers compared a special dialysis method that adjusts salt levels (sodium profiling) to standard dialysis. The goal was to see if the special method helps keep blood pres…

This study tested whether quickly removing a small amount of fluid during dialysis can help predict if a patient needs more fluids. Twenty critically ill adults with acute kidney injury on continuous dialysis took part. Researchers compared two speeds of fluid removal to a standa…

This study looked at 400 adults having scheduled, complex heart surgery to find a better way to detect acute kidney injury early. Researchers combined standard tests with newer biomarkers to create a score that could identify kidney problems within 6 hours after surgery. The goal…

This study tested whether giving nitric oxide during heart surgery can prevent acute kidney injury in patients with signs of blood vessel problems. Researchers studied 250 adults having long heart surgeries. The goal was to see if this simple gas treatment could protect kidney fu…

This study tested whether giving the acid-reducing drug pantoprazole during heart surgery could help prevent acute kidney injury. About 100 adults at moderate to high risk for kidney problems after surgery took part. Researchers compared pantoprazole to another drug, famotidine, …

This study tested whether methylene blue, a medicine that affects blood vessel tone, can prevent low blood pressure during kidney dialysis in critically ill patients. 261 adults with acute kidney injury and low blood pressure or requiring blood pressure support took part. The goa…

This study looked at 35 adults having nose surgery to see if deliberately lowering blood pressure (permissive hypotension) can cause early, hidden kidney injury. Researchers used sensitive blood tests (NGAL and cystatin C) to detect damage that standard tests might miss. The goal…

This study looked at whether using dialysis less often helps people with acute kidney injury recover kidney function faster. It involved 220 hospitalized adults who needed dialysis. The goal was to see if a conservative approach (less frequent dialysis) leads to more patients bei…

This study looked at 50 people with septic shock to see if levels of a protein called vasorin could predict how severe their kidney injury might be and their risk of dying. Researchers measured vasorin in the blood on the day of diagnosis and three days later. The goal was to fin…

This study tested a computer system that alerts pharmacists when hospitalized patients are at high risk for kidney injury caused by medications. The pharmacists then worked with doctors to adjust treatments. The goal was to see if this approach could reduce serious kidney complic…

This study looked at how very hard exercise temporarily affects the kidneys in 40 active adults. Researchers used special urine tests to detect early signs of kidney stress that standard blood tests might miss. The goal was to better understand why some athletes experience short-…

This study measured certain proteins in the blood and urine of 20 adults newly diagnosed with multiple myeloma who were starting treatment with daratumumab. The goal was to see if these markers could help detect acute kidney injury early. Participants provided samples at the star…

This study tested whether a computer model could predict kidney damage from platinum-based chemotherapy more accurately than doctors. Researchers collected data from 77 cancer patients in Taiwan and tracked their kidney function after treatment. The goal was to see if machine lea…

This study looked at 174 older adults (ages 65-80) having lumbar fusion surgery to see if one type of IV fluid (sodium acetate Ringer's) protects the kidneys better than another (sodium lactate Ringer's). Researchers measured kidney injury markers in urine and blood after surgery…

This study tested a new way to send alerts to doctors when a patient develops acute kidney injury (AKI). Instead of alerting for every case, researchers used a computer model to identify which patients would benefit most from the warning. Over 2,000 adults with AKI took part. The…

This study looked back at medical records of 238 severely burned adults who needed continuous kidney therapy (CRRT) in the intensive care unit. Researchers wanted to see how the timing of starting this therapy and the severity of kidney injury related to survival and length of ho…

This study tested whether using a bedside ultrasound to check how well patients with acute kidney injury can handle extra fluids is practical. 80 hospitalized adults (not in the ICU) were randomly assigned to either usual care or care guided by ultrasound results. The main goal w…

This study looked at 76 adults with severe pneumonia who needed a lung machine (ECMO) in the intensive care unit. Researchers wanted to see if giving the lungs a rest with this machine changed how well the kidneys worked. They used information already collected from patients, so …

This study looked at whether the pain medicine gabapentin harms kidney function after laparoscopic sleeve gastrectomy (weight-loss surgery) in people with severe obesity. 90 patients with normal kidneys were enrolled. Researchers measured kidney markers in blood and urine before …

This study looked back at the medical records of 455 adults who had heart surgery with a heart-lung machine. The goal was to see if simple blood tests taken before surgery could help predict if a patient would develop acute kidney injury afterward. The researchers hope their find…

This study looked back at the records of 400 adults in intensive care with septic shock and acute kidney injury who needed dialysis. It compared those who used a special filter called Oxiris, which also removes toxins and inflammation, to those who used standard filters. The goal…

This study looked at whether taking ibuprofen before exercising in the heat increases signs of kidney injury. Twelve physically active adults took either ibuprofen or a placebo before running for an hour in a hot room (35°C). Researchers measured kidney injury markers in their bl…

This study tested a prediction tool to see if it could accurately forecast kidney injury after heart surgery. Researchers looked at lab results from 2,500 adults to validate the model. The goal is to catch kidney problems early and start treatment sooner.

This study aimed to find better ways to predict kidney injury after heart surgery. Researchers tested new biomarkers in over 3,000 patients who developed kidney problems within two days of surgery. The goal was to see if these tests could identify which patients would get worse o…

This study aimed to create a tool that helps doctors decide which patients with severe acute kidney injury should see a kidney specialist after leaving the hospital. Researchers looked at 319 patients who needed dialysis for kidney injury and tracked their recovery. The goal was …

This study looked at how COVID-19 causes organ failure in intensive care patients. Researchers tracked 380 adults with suspected or confirmed COVID-19 in the ICU, measuring kidney injury, breathing problems, and survival rates. The goal was to better understand the disease, not t…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their hearts were working before giving them extra fluids. The goal was to…

This study looked at over 5,000 critically ill children from around the world to learn more about acute kidney injury (AKI). The goal was to better understand how common AKI is, what puts children at risk, and how to predict it using a tool called "renal angina." No new treatment…