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Urine test after a single dose of furosemide may spot kidney danger in ICU patients

NCT ID NCT07688733

Diagnosis Sponsor: Maithe Caroline Inacio Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests whether a quick urine measurement after a single dose of furosemide (a water pill) can predict which ICU patients with low albumin levels will develop severe acute kidney injury. Researchers will compare this test to blood biomarkers to see which is more accurate. The goal is to find a simple, bedside tool to identify high-risk patients early.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Furosemide Stress Test (diagnostic test using furosemide)
What this could lead to
If successful, this could help doctors identify which ICU patients with low albumin are at highest risk of severe kidney injury, enabling earlier intervention.
What could go wrong
This is a small, early-stage diagnostic study with only 55 participants. The test may not prove accurate enough for routine clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

55 people

The number who actually took part.

Started

Jun 2022

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Serum albumin \< 3 g/dL (hypoalbuminemia) * AKI diagnosed per KDIGO 2012 criteria, stage 1 or 2 * Adequate fluid resuscitation at discretion of treating nephrologist * Cellular casts in urinary sediment (George Washington Urine Sediment Score \> 2) or fractional excretion of sodium (FENa) \> 1% * Foley catheter in place * Written informed consent obtained Exclusion Criteria: * Age under 18 years * Pregnancy * Obstructive urinary pathology * Active bleeding * Allergy or hypersensitivity to loop diuretics * AKI stage 3 (KDIGO) at enrollment * Inadequate fluid resuscitation prior to the stress test * Known chronic kidney disease with eGFR \< 30 mL/min/1.73 m² (CKD-EPI equation)

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Conditions

The condition(s) this trial relates to.

acute kidney injury Hypoalbuminemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Hypoalbuminemia

Contacts and locations

Locations

  • Hospital Universitario "Dr. José Eleuterio González"

    Monterrey, Nuevo León, 64460, Mexico

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