Ibuprofen before a hot run may stress kidneys, small study finds

NCT ID NCT06247462

Completed Knowledge-focused Sponsor: University of New Mexico Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether taking ibuprofen before running in the heat increases signs of kidney injury. Twelve healthy adults took either ibuprofen or a placebo before running for an hour in a hot room. Researchers measured kidney injury markers in urine and blood before, right after, and one hour after exercise. The goal was to see if ibuprofen makes the kidneys more vulnerable to heat and exercise stress.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ibuprofen
What this could lead to: If it works, this could help clarify whether taking ibuprofen before exercise in the heat is safe for the kidneys.
What could go wrong: This is a very small, early-phase study with only 12 participants. Results may not apply to everyone, and the study only looked at short-term markers, not actual kidney damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY

Contacts and locations

Locations

Exercise Physiology Lab

Albuquerque, New Mexico, 87131, United States

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