Can blood filtering or a cancer drug save kidneys in myeloma patients?
NCT ID NCT06483139
First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 3 times
Summary
This study looks at two treatments—plasma exchange (a blood-filtering procedure) and the drug daratumumab—to see if they help patients with multiple myeloma recover from acute kidney injury caused by light chain cast nephropathy. Researchers will track 450 adults to see who survives with better kidney function within 90 days. The goal is to find which approach works best for this serious complication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Daratumumab (a drug) and plasma exchange (a procedure that filters the blood)
- What this could lead to
- If successful, this could show that plasma exchange or daratumumab helps more patients recover kidney function after myeloma-related kidney injury.
- What could go wrong
- This is an observational study, not a controlled trial, so results may not prove cause and effect. Kidney recovery depends on many factors, and benefits may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
Boston, Massachusetts, 02130, United States
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