New anticoagulation strategy tested for dialysis circuits in ECMO patients
NCT ID NCT05148026
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding regional citrate anticoagulation (RCA) to standard heparin can reduce clotting in continuous kidney dialysis circuits for patients on ECMO. Eighteen ICU adults with ARDS and acute kidney injury were enrolled. Each patient received alternating periods with and without citrate to compare circuit clotting rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Regional citrate anticoagulation (RCA) plus unfractionated heparin
What this could lead to
If adding citrate works, it could reduce clotting in dialysis circuits during ECMO, making treatment safer and more efficient for critically ill patients.
What could go wrong
This is a very small, early-stage study (18 patients) testing a technique already used in other settings. Results may not apply broadly, and adding citrate could increase bleeding or metabolic risks.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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ASST MONZA-Rianimazione Generale
Monza, Italy, 20900, Italy