Could a safer sedative shield kidneys during major abdominal surgery?
NCT ID NCT07674719
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This trial compares two sedatives—remimazolam and propofol—given during liver or pancreas surgery to see which better prevents acute kidney injury after the operation. The study includes adults aged 19 to 85 scheduled for elective hepatobiliary-pancreatic surgery. Researchers aim to find out if remimazolam helps maintain stable blood pressure and reduces kidney damage, especially when fluid intake is limited during surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- remimazolam
- What this could lead to
- If remimazolam proves better at protecting kidney function, it could become a preferred sedative for surgeries where fluid intake is limited.
- What could go wrong
- This is a small, early-stage trial with only 78 participants, so results may not apply broadly. Remimazolam may not reduce kidney injury more than propofol.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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