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Simple cuff trick may shield heart failure patients from kidney damage

NCT ID NCT04982419

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with congestive heart failure. About 240 participants will be randomly assigned to receive either the real cuff inflations or a sham version. The goal is to see if this simple technique reduces kidney injury and improves walking ability after one month.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Remote ischemic preconditioning (blood pressure cuff inflations)
What this could lead to
If it works, this simple, non-drug technique could reduce kidney injury and improve recovery in heart failure patients after heart procedures.
What could go wrong
This is a mid-stage trial with 240 participants, so results are not yet proven. The benefit may be small or not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome acute kidney injury coronary artery disorder heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY CONTRAST-INDUCED NEPHROPATHY CORONARY ANGIOGRAPHY HEART FAILURE PERCUTANEOUS CORONARY INTERVENTION

Contacts and locations

Locations

  • Hunter Holmes McGuire VA Medical Center, Richmond, VA

    RECRUITING

    Richmond, Virginia, 23249-0001, United States

  • VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX

    RECRUITING

    Dallas, Texas, 75216-7167, United States

  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

    RECRUITING

    Pittsburgh, Pennsylvania, 15240, United States

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