Could a single drug shield kidneys during heart surgery?
NCT ID NCT07625553
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the drug R2R01 can prevent acute kidney injury in people at high risk who are having heart surgery with a heart-lung machine. Participants receive either R2R01 or a placebo before and after surgery. The goal is to see if the drug reduces kidney damage and related complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
R2R01 (a relaxin agonist)
What this could lead to
If successful, this could lead to a new way to prevent kidney damage after heart surgery, reducing complications and hospital stays.
What could go wrong
This is an early phase 2 trial, so the drug may not prove effective or safe. Possible side effects are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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IRCSS San Raffaele
RECRUITINGMilan, 20132, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••