Could stem cells shield kidneys after severe injury?

NCT ID NCT06654193

Recruiting now Disease control Sponsor: Hope Biosciences LLC Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether stem cells from donated fat tissue can prevent kidney injury from getting worse in people who have been severely hurt in accidents or burns. About 70 ICU patients will receive either stem cells or a placebo. The goal is to see if the treatment is safe and helps kidneys recover faster, reducing the need for dialysis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Allogeneic adipose-derived mesenchymal stem cells (HB-adMSCs)
What this could lead to: If it works, this could point toward a treatment that prevents acute kidney injury from getting worse after severe trauma or burn, reducing the need for dialysis.
What could go wrong: This is an early Phase 1/2 trial with only 70 participants, so results are preliminary. Stem cell infusions carry risks like allergic reactions or infection, and the treatment may not improve kidney function.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY

Contacts and locations

Locations

University of Alabama at Birmingham
NOT_YET_RECRUITING

Birmingham, Alabama, 35294, United States
University of California, San Francisco
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
University of Texas Health Science Center at Houston (UTHealth Houston)
RECRUITING

Houston, Texas, 77479, United States

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