Could a common heartburn drug shield kidneys after trauma?

NCT ID NCT06531642

Recruiting now Disease control Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving the acid-reducing drug pantoprazole (Protonix) early after a traumatic injury with severe bleeding can lower the risk of acute kidney injury. Researchers will compare early dosing (within 2 hours of arrival) to usual timing (in the ICU) in 100 adult trauma patients. They will measure kidney injury markers and track kidney function for up to 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pantoprazole (Protonix)
What this could lead to: If it works, this could show that giving pantoprazole early after trauma helps prevent kidney damage in patients with severe bleeding.
What could go wrong: This is a small, early-phase trial (Phase 2/3) with only 100 patients, so results may not apply to everyone. The main goal is to check kidney injury markers, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury Shock, Hemorrhagic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY

Contacts and locations

Locations

Memorial Hermann Texas Medical Center
RECRUITING

Houston, Texas, 77030, United States

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